R. Ceriani, J. Peterson, J. Lee, R. Moncada, and E. Blank, Characterization of cell surface antigens of human mammary epithelial cells with monoclonal antibodies prepared against human milk fat globule, Somatic Cell Genetics, vol.51, issue.4, pp.415-427, 1983.
DOI : 10.1007/BF01543043

J. Stubbs, C. Lekutis, K. Singer, A. Bui, and D. Yuzuki, cDNA cloning of a mouse mammary epithelial cell surface protein reveals the existence of epidermal growth factor-like domains linked to factor VIII-like sequences., Proceedings of the National Academy of Sciences, vol.87, issue.21, pp.8417-8421, 1990.
DOI : 10.1073/pnas.87.21.8417

K. Oshima, N. Aoki, T. Kato, K. Kitajima, and T. Matsuda, Secretion of a peripheral membrane protein, MFG-E8, as a complex with membrane vesicles, European Journal of Biochemistry, vol.3, issue.19, 2002.
DOI : 10.1046/j.1432-1033.2002.02758.x

R. Hanayama, M. Tanaka, K. Miwa, A. Shinohara, and A. Iwamatsu, Identification of a factor that links apoptotic cells to phagocytes, Nature, vol.120, issue.6885, pp.182-187, 2002.
DOI : 10.1021/bi963119m

M. Jinushi, Y. Nakazaki, M. Dougan, D. Carrasco, and M. Mihm, MFG-E8???mediated uptake of apoptotic cells by APCs links the pro- and antiinflammatory activities of GM-CSF, Journal of Clinical Investigation, vol.117, issue.7, pp.1902-1913, 2007.
DOI : 10.1172/JCI30966DS1

R. Hanayama, M. Tanaka, K. Miyasaka, K. Aozasa, and M. Koike, Autoimmune Disease and Impaired Uptake of Apoptotic Cells in MFG-E8-Deficient Mice, Science, vol.304, issue.5674, pp.1147-1150, 2004.
DOI : 10.1126/science.1094359

C. Hu, C. Wu, H. Tsai, S. Chang, and W. Tsai, Genetic polymorphism in milk fat globule-EGF factor 8 (MFG-E8) is associated with systemic lupus erythematosus in human, Lupus, vol.16, issue.8, pp.676-681, 2009.
DOI : 10.1177/0961203309103027

J. Silvestre, C. Thery, G. Hamard, J. Boddaert, and B. Aguilar, Lactadherin promotes VEGF-dependent neovascularization, Nature Medicine, vol.103, issue.5, pp.499-506, 2005.
DOI : 10.1038/nm0102-27

R. Young and D. Bok, PARTICIPATION OF THE RETINAL PIGMENT EPITHELIUM IN THE ROD OUTER SEGMENT RENEWAL PROCESS, The Journal of Cell Biology, vol.42, issue.2, pp.392-403, 1969.
DOI : 10.1083/jcb.42.2.392

R. Edwards and R. Szamier, Defective phagocytosis of isolated rod outer segments by RCS rat retinal pigment epithelium in culture, Science, vol.197, issue.4307, pp.1001-1003, 1977.
DOI : 10.1126/science.560718

E. Nandrot, E. Dufour, A. Provost, M. Pequignot, and S. Bonnel, Homozygous Deletion in the Coding Sequence of the c-mer Gene in RCS Rats Unravels General Mechanisms of Physiological Cell Adhesion and Apoptosis, Neurobiology of Disease, vol.7, issue.6, pp.586-599, 2000.
DOI : 10.1006/nbdi.2000.0328

D. Cruz, P. Yasumura, D. Weir, J. Matthes, M. Abderrahim et al., Mutation of the receptor tyrosine kinase gene Mertk in the retinal dystrophic RCS rat, Human Molecular Genetics, vol.9, issue.4, pp.645-651, 2000.
DOI : 10.1093/hmg/9.4.645

S. Finnemann, V. Bonilha, A. Marmorstein, and E. Rodriguez-boulan, Phagocytosis of rod outer segments by retinal pigment epithelial cells requires ??v??5 integrin for binding but not for internalization, Proceedings of the National Academy of Sciences, vol.94, issue.24, pp.12932-12937, 1997.
DOI : 10.1073/pnas.94.24.12932

B. Burgess, T. Abrams, S. Nagata, and M. Hall, MFG-E8 in the retina and retinal pigment epithelium of rat and mouse, Mol Vis, vol.12, pp.1437-1447, 2006.

E. Nandrot, M. Anand, D. Almeida, K. Atabai, and D. Sheppard, Essential role for MFG-E8 as ligand for ??vbeta5 integrin in diurnal retinal phagocytosis, Proceedings of the National Academy of Sciences, vol.104, issue.29, pp.12005-12010, 2007.
DOI : 10.1073/pnas.0704756104

M. Houssier, R. W. Lavalette, S. Keller, N. Guillonneau, and X. , CD36 Deficiency Leads to Choroidal Involution via COX2 Down-Regulation in Rodents, PLoS Medicine, vol.278, issue.2, p.39, 2008.
DOI : 10.1371/journal.pmed.0050039.g004
URL : https://hal.archives-ouvertes.fr/inserm-00258554

D. Friedman, O. Colmain, B. Munoz, B. Tomany, S. Mccarty et al., Prevalence of age-related macular degeneration in the United States, Arch Ophthalmol, vol.122, pp.564-572, 2004.

S. Sarks, Ageing and degeneration in the macular region: a clinico-pathological study., British Journal of Ophthalmology, vol.60, issue.5, pp.324-341, 1976.
DOI : 10.1136/bjo.60.5.324

P. Rosenfeld, D. Brown, J. Heier, D. Boyer, and P. Kaiser, Ranibizumab for Neovascular Age-Related Macular Degeneration, New England Journal of Medicine, vol.355, issue.14, pp.1419-1431, 2006.
DOI : 10.1056/NEJMoa054481

R. Klein, T. Peto, A. Bird, and M. Vannewkirk, The epidemiology of age-related macular degeneration, American Journal of Ophthalmology, vol.137, issue.3, pp.486-495, 2004.
DOI : 10.1016/j.ajo.2003.11.069

X. Ding, M. Patel, and C. Chan, Molecular pathology of age-related macular degeneration, Progress in Retinal and Eye Research, vol.28, issue.1, pp.1-18, 2009.
DOI : 10.1016/j.preteyeres.2008.10.001

C. Augood, J. Vingerling, P. De-jong, U. Chakravarthy, and J. Seland, Prevalence of Age-Related Maculopathy in Older Europeans, Archives of Ophthalmology, vol.124, issue.4, pp.529-535, 2006.
DOI : 10.1001/archopht.124.4.529

A. Bird, N. Bressler, S. Bressler, I. Chisholm, and G. Coscas, An international classification and grading system for age-related maculopathy and age-related macular degeneration, Survey of Ophthalmology, vol.39, issue.5, pp.367-374, 1995.
DOI : 10.1016/S0039-6257(05)80092-X

T. Vinding, M. Appleyard, J. Nyboe, and G. Jensen, Risk factor analysis for atrophic and exudative age-related macular degeneration, Acta Ophthalmologica, vol.5, issue.Supp, pp.66-72, 1992.
DOI : 10.1111/j.1755-3768.1992.tb02093.x

R. Klein, B. Klein, K. Linton, and D. Demets, The Beaver Dam Eye Study: The Relation of Age-related Maculopathy to Smoking, American Journal of Epidemiology, vol.137, issue.2, pp.190-200, 1993.
DOI : 10.1093/oxfordjournals.aje.a116659

C. Combadiere, C. Feumi, R. W. Keller, N. Rodero, and M. , CX3CR1-dependent subretinal microglia cell accumulation is associated with cardinal features of age-related macular degeneration, Journal of Clinical Investigation, vol.117, issue.10, pp.2920-2928, 2007.
DOI : 10.1172/JCI31692DS1
URL : https://hal.archives-ouvertes.fr/inserm-00176389

H. Baatz, L. Poupel, M. Coudert, F. Sennlaub, and C. Combadiere, Komplementfaktor-Polymorphismen und altersassoziierte Makuladegeneration in einer Gruppe??deutscher Patienten, Klinische Monatsbl??tter f??r Augenheilkunde, vol.226, issue.08, pp.654-658, 2009.
DOI : 10.1055/s-0028-1109318

P. Sasieni, From Genotypes to Genes: Doubling the Sample Size, Biometrics, vol.53, issue.4, pp.1253-1261, 1997.
DOI : 10.2307/2533494

D. Tregouet and V. Garelle, A new JAVA interface implementation of THESIAS: testing haplotype effects in association studies, Bioinformatics, vol.23, issue.8, pp.1038-1039, 2007.
DOI : 10.1093/bioinformatics/btm058

M. Paques, J. Guyomard, M. Simonutti, M. Roux, and S. Picaud, Panretinal, High-Resolution Color Photography of the Mouse Fundus, Investigative Opthalmology & Visual Science, vol.48, issue.6, pp.2769-2774, 2007.
DOI : 10.1167/iovs.06-1099

A. Swaroop, K. Branham, W. Chen, and G. Abecasis, Genetic susceptibility to age-related macular degeneration: a paradigm for dissecting complex disease traits, Human Molecular Genetics, vol.16, issue.R2, pp.174-182, 2007.
DOI : 10.1093/hmg/ddm212

W. Green and C. Enger, Age-related Macular Degeneration Histopathologic Studies, Ophthalmology, vol.100, issue.10, pp.1519-1535, 1993.
DOI : 10.1016/S0161-6420(93)31466-1

K. Atabai, J. S. Azhar, N. Kuo, A. Lam, and M. , Mfge8 diminishes the severity of tissue fibrosis in mice by binding and targeting collagen for uptake by macrophages, Journal of Clinical Investigation, vol.119, issue.12, pp.3713-3722, 2009.
DOI : 10.1172/JCI40053DS1

N. Kwak, N. Okamoto, J. Wood, and P. Campochiaro, VEGF is major stimulator in model of choroidal neovascularization, Invest Ophthalmol Vis Sci, vol.41, pp.3158-3164, 2000.

H. Kamizuru, H. Kimura, T. Yasukawa, Y. Tabata, and Y. Honda, Monoclonal antibody-mediated drug targeting to choroidal neovascularization in the rat, Invest Ophthalmol Vis Sci, vol.42, pp.2664-2672, 2001.

G. Sugano, I. Bernard-pierrot, M. Lae, C. Battail, and Y. Allory, Milk fat globule???epidermal growth factor???factor VIII (MFGE8)/lactadherin promotes bladder tumor development, Oncogene, vol.10, issue.6, pp.642-653, 2010.
DOI : 10.1158/1541-7786.MCR-07-0344

E. Nandrot and S. Finnemann, Lack of αvβ5 Integrin Receptor or Its Ligand MFG-E8: Distinct Effects on Retinal Function, Ophthalmic Research, vol.40, issue.3-4, pp.120-123, 2008.
DOI : 10.1159/000119861