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IDH2 mutations are frequent in angioimmunoblastic T-cell lymphoma.: IDH2 mutations in AITL

Abstract : Mutations in isocitrate dehydrogenase 1 (IDH1) and isocitrate dehydrogenase 2 (IDH2) occur in most grade 2 and 3 gliomas, secondary glioblastomas, and a subset of acute myelogenous leukemias but have not been detected in other tumor types. The mutations occur at specific arginine residues and result in the acquisition of a novel enzymatic activity that converts 2-oxoglutarate to D-2-hydroxyglutarate. This study reports IDH1 and IDH2 genotyping results from a set of lymphomas, which included a large set of peripheral T-cell lymphomas. IDH2 mutations were identified in approximately 20% of angioimmunoblastic T-cell lymphomas (AITLs), but not in other peripheral T-cell lymphoma entities. These results were confirmed in an independent set of AITL patients, where the IDH2 mutation rate was approximately 45%. This is the second common genetic lesion identified in AITL after TET2 and extends the number of neoplastic diseases where IDH1 and IDH2 mutations may play a role.
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Submitted on : Tuesday, July 3, 2012 - 7:00:09 AM
Last modification on : Wednesday, June 1, 2022 - 4:05:18 AM
Long-term archiving on: : Thursday, October 4, 2012 - 2:18:24 AM


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Rob A. Cairns, Javeed Iqbal, François Lemonnier, Can Kucuk, Laurence de Leval, et al.. IDH2 mutations are frequent in angioimmunoblastic T-cell lymphoma.: IDH2 mutations in AITL. Blood, American Society of Hematology, 2012, 119 (8), pp.1901-3. ⟨10.1182/blood-2011-11-391748⟩. ⟨inserm-00689602⟩



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