[Impact of late treatment-related radiotherapy toxicity, depression, and anxiety on quality of life in long-term breast cancer survivors].

Abstract : INTRODUCTION: This study aimed to assess the impact of late treatment toxicity (especially radiotherapy toxicity), chemoradiotherapy treatment type (concurrent or sequential), depression and anxiety on overall, physical and emotional quality of life (QoL) in long-term breast cancer survivors. Method. We assessed 117 patients (mean follow-up since the end of treatment = 8.1 years) for late radiotherapy toxicity (LENT-SOMA scale), patient and doctor ratings of breast cosmetic outcomes, QoL (EORTC QLQ-C30), depression and anxiety (Hospital and Anxiety Depression scale). RESULTS: In univariate analyses, factors associated with significantly decreased QoL were: use of sequential treatment and decreased overall QoL (P = 0.002) and emotional QoL (P = 0.02) ; few radiotherapy late toxicity symptoms (pain and decreased physical QoL, P = 0.01 ; fibrosis and decreased emotional QoL, P = 0.04) ; probable depression or probable anxiety and decreased overall, physical and emotional QoL (P ≤ 0.005). In multivariate analyses, probable depression and probable anxiety were the most stronger predictors for decreased QoL in the overall, physical and emotional domains (P ≤ 0.02). CONCLUSION: Improving screening for and treatment of depression and anxiety might improve QoL in long-term breast cancer survivors.
Type de document :
Article dans une revue
Bulletin du Cancer, John Libbey Eurotext, 2012, 99 (5), pp.589-98. 〈10.1684/bdc.2012.1569〉
Liste complète des métadonnées

Littérature citée [33 références]  Voir  Masquer  Télécharger

http://www.hal.inserm.fr/inserm-00686640
Contributeur : Paul Brunault <>
Soumis le : jeudi 22 mai 2014 - 09:24:19
Dernière modification le : mardi 12 juin 2018 - 19:18:02
Document(s) archivé(s) le : vendredi 22 août 2014 - 10:36:27

Fichiers

Main_Document_Bulletin_du_Canc...
Fichiers produits par l'(les) auteur(s)

Identifiants

Collections

Citation

Paul Brunault, Alain Toledano, Colette Aguerre, Isabelle Suzanne, Pascal Garaud, et al.. [Impact of late treatment-related radiotherapy toxicity, depression, and anxiety on quality of life in long-term breast cancer survivors].. Bulletin du Cancer, John Libbey Eurotext, 2012, 99 (5), pp.589-98. 〈10.1684/bdc.2012.1569〉. 〈inserm-00686640〉

Partager

Métriques

Consultations de la notice

369

Téléchargements de fichiers

664