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Cyclin B in mouse oocytes and embryos: importance for human reproduction and aneuploidy.

Abstract : Oocyte maturation and early embryo development require precise coordination between cell cycle progression and the developmental programme. Cyclin B plays a major role in this process: its accumulation and degradation is critical for driving the cell cycle through activation and inactivation of the major cell cycle kinase, CDK1. CDK1 activation is required for M-phase entry whereas its inactivation leads to exit from M-phase. The tempo of oocyte meiotic and embryonic mitotic divisions is set by the rate of cyclin B accumulation and the timing of its destruction. By controlling when cyclin B destruction is triggered and by co-ordinating this with the completion of chromosome alignment, the spindle assembly checkpoint (SAC) is a critical quality control system important for averting aneuploidy and for building in the flexibility required to better integrate cell cycle progression with development. In this review we focus on cyclin B metabolism in mouse oocytes and embryos and illustrate how the cell cycle-powered clock (in fact cyclin B-powered clock) controls oocyte maturation and early embryo development, thereby providing important insight into human reproduction and potential causes of Down syndrome.
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Contributor : Hervé De Villemeur Connect in order to contact the contributor
Submitted on : Tuesday, April 3, 2012 - 10:21:02 AM
Last modification on : Wednesday, March 30, 2022 - 2:35:08 PM



Zbigniew Polanski, Hayden Homer, Jacek Z. Kubiak. Cyclin B in mouse oocytes and embryos: importance for human reproduction and aneuploidy.. Results and Problems in Cell Differentiation, Springer-verlag Berlin Heidelberg, 2012, Results and Problems in Cell Differentiation - 56, 55, pp.69-91. ⟨10.1007/978-3-642-30406-4_4⟩. ⟨inserm-00684765⟩



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