Skip to Main content Skip to Navigation
Journal articles

[Improving donor heart preservation ex vivo].: Improving donor heart preservation ex vivo

Abstract : There is a shortage of heart donors. Some available organs are lost through deterioration prior to transplantation. Indeed, from the moment of brain death until reperfusion in the recipient, cardiac grafts (and also kidney, lung and liver grafts) can undergo irreversible damage due to cardioplegia, the harvesting procedure, and hypothermic transport. The noxious phenomena occurring during cold ischaemia and myocardial reperfusion have been studied for more than 40 years. It was long believed that only the ischaemic phase was harmful, through depletion of energy stores, ionic imbalance, and metabolic disruption. We now know that the heart graft can also be damaged during the reperfusion phase, through calcium overload, free radical production, and mitochondrial changes. Preconditioning and post-conditioning procedures are being developed to protect the ischemic organ.
Complete list of metadata

Cited literature [14 references]  Display  Hide  Download
Contributor : René Ferrera Connect in order to contact the contributor
Submitted on : Wednesday, March 21, 2012 - 12:20:48 PM
Last modification on : Monday, June 28, 2021 - 9:50:07 AM
Long-term archiving on: : Wednesday, December 14, 2016 - 5:42:06 PM


 Restricted access
To satisfy the distribution rights of the publisher, the document is embargoed until : jamais

Please log in to resquest access to the document


  • HAL Id : inserm-00681359, version 1
  • PRODINRA : 245334
  • PUBMED : 22375357
  • WOS : 000299590900008



René Ferrera, Souhila Benhabbouche. [Improving donor heart preservation ex vivo].: Improving donor heart preservation ex vivo. Bulletin de l'Académie Nationale de Médecine, Elsevier Masson, 2011, 195 (4-5), pp.861-78; discussion 878-81. ⟨inserm-00681359⟩



Record views