Cumulative pregnancy rate after ICSI-IVF in patients with colorectal endometriosis: results of a multicentre study.

Marcos Ballester 1, * Emmanuelle Mathieu D'Argent 1 Karine Morcel 1 Joëlle Belaisch-Allart 2 Michelle Nisolle 3 Emile Daraï 1
* Auteur correspondant
1 Service de Gynécologie-Obstétrique [CHU Tenon]
2 Service de Gynécologie-Obstétrique
3 Service de Gynécologie-Obstétrique
Abstract : BACKGROUNDThere is currently no consensus about indications for surgery for infertility associated with colorectal endometriosis. The aim of this study was to evaluate cumulative pregnancy rates (CPRs) after ICSI-IVF cycles in patients with colorectal endometriosis and to identify determinant factors of fertility outcome.METHODSProspective longitudinal multicentre study from January 2005 to June 2011. We included 75 patients with colorectal endometriosis and proved infertility without prior surgery for deep infiltrating endometriosis. Univariable analysis was used to identify determinant factors of pregnancy rate. CPR was calculated using cumulative-incidence methods from log-rank test and Kaplan-Meier curves. For multivariable analysis, Cox proportional hazards model was used.RESULTSFor CPR per patient analysis, the total number of cycles was 113 and the median number of cycles per patient was 1 (range: 1-3). In the whole population the CPR per patient after three ICSI-IVF cycles was 68.6%. The CPR for patients with or without associated adenomyosis was 19 and 82.4%, respectively (P= 0.01). In addition, a patient age over 35 years (P= 0.02) and anti-Mullerian hormone serum level under 2 ng/ml (P= 0.02) were associated with a decreased CPR per patient. At multivariable analysis, adenomyosis [HR = 0.34, 95% CI (0.12-0.99), P= 0.49] was associated with a decreased CPR.CONCLUSIONSOur data confirm that ICSI-IVF offers a high CPR per patient. However, determinant factors of CPR should be taken into account when informing couples of their options.
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Article dans une revue
Human Reproduction, Oxford University Press (OUP), 2012, 27 (4), pp.1043-1049. 〈10.1093/humrep/des012〉
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http://www.hal.inserm.fr/inserm-00679258
Contributeur : Hervé De Villemeur <>
Soumis le : jeudi 15 mars 2012 - 11:27:03
Dernière modification le : lundi 26 mars 2018 - 14:42:44

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IGDR | BIOSIT | UR1-UFR-SVE | UNIV-RENNES

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Marcos Ballester, Emmanuelle Mathieu D'Argent, Karine Morcel, Joëlle Belaisch-Allart, Michelle Nisolle, et al.. Cumulative pregnancy rate after ICSI-IVF in patients with colorectal endometriosis: results of a multicentre study.. Human Reproduction, Oxford University Press (OUP), 2012, 27 (4), pp.1043-1049. 〈10.1093/humrep/des012〉. 〈inserm-00679258〉

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