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Factors associated with fatigue in early arthritis: Results from the ESPOIR cohort.

Abstract : OBJECTIVES: Fatigue is frequent in patients with early arthritis (EA). Determinants of its severity are unknown. We aimed to identify the factors associated with fatigue in EA and changes in fatigue after 1-year follow-up. METHOD: ESPOIR is a multicentre, prospective, national cohort of patients with EA. At baseline and every 6 months up to 1 year, we recorded sociodemographic, clinical and treatment characteristics, AIMS2-SF and SF-36 scores for health-related quality of life (HRQoL), and fatigue severity by a visual analogue scale (f-VAS) and the SF-36 vitality score (fatigue_SF36). RESULTS: We included 813 patients (48±13 years old, 77% women). At baseline, fatigue as assessed by the f-VAS or fatigue_SF36 was independently associated with young age, female sex, low education level, smoking, increased DAS-28, waking up at night, Sjögren syndrome and worse AIMS2-SF physical, affect and symptom scores. At 1-year follow-up, a favorable change in fatigue scores was associated with increased baseline AIMS2-SF physical and affect scores (better QoL), high baseline fatigue scores, and improved 1-year AIMS2-SF affect scores. Age, sex, and change in AIMS2-SF physical score, DAS-28, and haemoglobin or C-reactive protein level were inconsistently associated with change in fatigue scores. The AIMS2-SF affect score explained most of the variance in baseline fatigue score and was an important factor in 1-year change in fatigue score. CONCLUSION: Fatigue in EA is multifactorial. Its level and its course are strongly associated with HRQoL, notably the affect dimension. These results should help professionals inform patients about fatigue, explore its causes and develop tailored interventions. © 2012 by the American College of Rheumatology.
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Submitted on : Thursday, March 8, 2012 - 11:53:47 AM
Last modification on : Tuesday, April 19, 2022 - 10:14:15 AM

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Anne-Christine Rat, Jacques Pouchot, Bruno Fautrel, Patrick Boumier, Philippe Goupille, et al.. Factors associated with fatigue in early arthritis: Results from the ESPOIR cohort.. Arthritis Care & Research = Arthritis Care and Research, Wiley-Blackwell, 2012, epub ahead of print. ⟨10.1002/acr.21647⟩. ⟨inserm-00677428⟩



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