Service interruption on Monday 11 July from 12:30 to 13:00: all the sites of the CCSD (HAL, EpiSciences, SciencesConf, AureHAL) will be inaccessible (network hardware connection).
Skip to Main content Skip to Navigation
Journal articles

Does the Framingham Stroke Risk Profile predict white-matter changes in late-life depression?: Vascular risk and white-matter changes in depression

Abstract : ABSTRACTBackground: Cardiovascular risk factors and diseases are important etiological factors in depression, particularly late-life depression. Brain changes associated with vascular disease and depression can be detected using magnetic resonance imaging. Using diffusion tensor imaging (DTI), we investigated whether the Framingham Stroke Risk Profile (FSRP), a well-validated risk prediction algorithm, is associated with changes in white-matter connectivity. We hypothesized that depressed participants would show reduced white-matter integrity with higher FSRP, and non-depressed controls (matched for mean vascular risk) would show minimal co-variance with white-matter changes.Methods: Thirty-six participants with major depression (age 71.8 ± 7.7 years, mean FSRP 10.3 ± 7.6) and 25 controls (age 71.8 ± 7.3 years, mean FSRP 10.1 ± 7.7) were clinically interviewed and examined, followed by 60-direction DTI on a 3.0 Tesla scanner. Image analysis was performed using FSL tools ( to assess the correlation between FSRP and fractional anisotropy (FA). Voxelwise statistical analysis of the FA data was carried out using Tract Based Spatial Statistics. The significance threshold for correlations was set at p < 0.05 using threshold-free cluster-enhancement. Partial correlation analysis investigated significant correlations in each group.Results: Participants in the depressed group showed highly significant correlations between FSRP and FA within the body of corpus callosum (r = -0.520, p = 0.002), genu of corpus callosum (r = -0.468, p = 0.005), splenium of corpus callosum (r = -0.536, p = 0.001), and cortico-spinal tract (r = -0.473, p = 0.005). In controls, there was only one significant correlation in the body of corpus callosum (r = -0.473, p = 0.023).Conclusions: FSRP is associated with impairment in white-matter integrity in participants with depression; these results suggest support for the vascular depression hypothesis.
Document type :
Journal articles
Complete list of metadata

Cited literature [37 references]  Display  Hide  Download
Contributor : Annie Schmaus Connect in order to contact the contributor
Submitted on : Wednesday, March 7, 2012 - 3:30:13 PM
Last modification on : Sunday, June 26, 2022 - 11:55:45 AM
Long-term archiving on: : Wednesday, December 14, 2016 - 10:52:09 AM


Files produced by the author(s)




Charlotte L. Allan, Claire E. Sexton, Ukwuori G. Kalu, Lisa M. Mcdermott, Mika Kivimäki, et al.. Does the Framingham Stroke Risk Profile predict white-matter changes in late-life depression?: Vascular risk and white-matter changes in depression. International Psychogeriatrics, Cambridge University Press (CUP), 2011, pp.1-8. ⟨10.1017/S1041610211002183⟩. ⟨inserm-00677209⟩



Record views


Files downloads