High-pressure intrapleural chemotherapy: feasibility in the pig model. - Inserm - Institut national de la santé et de la recherche médicale Accéder directement au contenu
Article Dans Une Revue World Journal of Surgical Oncology Année : 2012

High-pressure intrapleural chemotherapy: feasibility in the pig model.

Résumé

ABSTRACT: BACKGROUND: The usual treatments for pleural malignancies are mostly palliative. In contrast, peritoneal malignancies are often treated with a curative intent by cytoreductive surgery and intraperitoneal chemotherapy. As pressure has been shown to increase antitumor efficacy, we applied the concept of high-pressure intracavitary chemotherapy to the pleural space in a swine model. METHODS: Cisplatin and gemcitabine were selected because of their antineoplasic efficacy in vitro in a wide spectrum of cancer cell lines. The pleural cavity of 21 pigs was filled with saline solution; haemodynamic and respiratory parameters were monitored. The pressure was increased to 15-25 cm H2O. This treatment was associated with pneumonectomy in 6 pigs. Five pigs were treated with chemotherapy under pressure. RESULTS: The combination of gemcitabine (100 mg/l) and cisplatin (30 mg/l) was highly cytotoxic in vitro. The maximum tolerated pressure was 20 cm H20, due to haemodynamic failure. Pneumonectomy was not tolerated, either before or after pleural infusion. Five pigs survived intrapleural chemotherapy associating gemcitabine and cisplatin with 20 cm H2O pressure for 60 min. CONCLUSIONS: High-pressure intrapleural chemotherapy is feasible in pigs. Further experiments will establish the pharmacokinetics and determine whether the benefit already shown in the peritoneum is also obtained in the pleura.

Domaines

Chirurgie Cancer
Fichier principal
Vignette du fichier
1477-7819-10-29.pdf (189.6 Ko) Télécharger le fichier
1477-7819-10-29.xml (57.48 Ko) Télécharger le fichier
Origine : Fichiers éditeurs autorisés sur une archive ouverte
Format : Autre
Loading...

Dates et versions

inserm-00675069 , version 1 (28-02-2012)

Identifiants

Citer

Olivier Facy, Pierre-Benoit Pages, Pablo Ortega-Deballon, Guy Magnin, Sylvain Ladoire, et al.. High-pressure intrapleural chemotherapy: feasibility in the pig model.. World Journal of Surgical Oncology, 2012, 10 (1), pp.29. ⟨10.1186/1477-7819-10-29⟩. ⟨inserm-00675069⟩
299 Consultations
219 Téléchargements

Altmetric

Partager

Gmail Facebook X LinkedIn More