Autophagy: A protective mechanism in response to stress and inflammation. - Inserm - Institut national de la santé et de la recherche médicale Access content directly
Journal Articles Current Opinion in Investigational Drugs Year : 2006

Autophagy: A protective mechanism in response to stress and inflammation.

Abstract

Autophagy is one of the intracellular systems that is responsible for protein trafficking (degradation/recycling) in eukaryotic cells. This ubiquitous process contributes to cytosolic homeostasis, but its deregulation is often associated with various pathologies, including neurodegenerative diseases and cancer and pathologies with an altered inflammatory response. This review provides an overview of autophagy and discusses its regulation, function and future therapeutic possibilities, with a focus on the role of autophagy in inflammation.

Domains

Rhumatology and musculoskeletal system
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https://www.hal.inserm.fr/inserm-00669003

Submitted on : Friday, February 10, 2012-6:29:46 PM

Last modification on : Wednesday, April 27, 2022-3:42:39 AM

Long-term archiving on: Friday, May 11, 2012-3:05:19 AM

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inserm-00669003 , version 1 (10-02-2012)

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  • HAL Id : inserm-00669003 , version 1
  • PUBMED : 16729721

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Dominique Heymann. Autophagy: A protective mechanism in response to stress and inflammation.. Current Opinion in Investigational Drugs, 2006, 7 (5), pp.443-50. ⟨inserm-00669003⟩

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