ASPM-associated stem cell proliferation is involved in malignant progression of gliomas and constitutes an attractive therapeutic target. - Archive ouverte HAL Access content directly
Journal Articles Cancer Cell International Year : 2010

ASPM-associated stem cell proliferation is involved in malignant progression of gliomas and constitutes an attractive therapeutic target.

(1) , (2) , (1) , (1) , (1) , (3) , (1) , (1, 4) , (1) , (5) , (5) , (1) , (1, 4) , (1, 4)
1
2
3
4
5
Pascal Leuraud
  • Function : Author
  • PersonId : 918657
Myriam Lassalle
  • Function : Author
  • PersonId : 918658

Abstract

BACKGROUND: ASPM (Abnormal Spindle-like Microcephaly associated) over-expression was recently implicated in the development of malignant gliomas. RESULTS: To better characterize the involvement of ASPM in gliomas, we investigated the mRNA expression in 175 samples, including 8 WHO Grade II, 75 WHO Grade III and 92 WHO Grade IV tumors. Aspm expression was strongly correlated with tumor grade and increased at recurrence when compared to the initial lesion, whatever the initial grade of the primary tumor. ASPM expression also increased over serial passages in gliomaspheres in vitro and in mouse xenografts in vivo. Lentivirus-mediated shRNA silencing of ASPM resulted in dramatic proliferation arrest and cell death in two different gliomasphere models. CONCLUSION: These data suggest that ASPM is involved in the malignant progression of gliomas, possibly through expansion of a cancer stem cell compartment, and is an attractive therapeutic target in glioblastoma multiforme.
Fichier principal
Vignette du fichier
1475-2867-10-1.pdf (2.94 Mo) Télécharger le fichier
Vignette du fichier
1475-2867-10-1-S1.PPT (185 Ko) Télécharger le fichier
Vignette du fichier
1475-2867-10-1-S2.PPT (888.5 Ko) Télécharger le fichier
Vignette du fichier
1475-2867-10-1-S3.PPT (109 Ko) Télécharger le fichier
Vignette du fichier
1475-2867-10-1.xml (39.12 Ko) Télécharger le fichier
Origin : Publisher files allowed on an open archive
Format : Other
Format : Other
Format : Other
Format : Other
Loading...

Dates and versions

inserm-00668477 , version 1 (09-02-2012)

Identifiers

Cite

Sandra-Nadia Ngwabyt Bikeye, Carole Colin, Yannick Marie, Raphaël Vampouille, Philippe Ravassard, et al.. ASPM-associated stem cell proliferation is involved in malignant progression of gliomas and constitutes an attractive therapeutic target.. Cancer Cell International, 2010, 10 (1), pp.1. ⟨10.1186/1475-2867-10-1⟩. ⟨inserm-00668477⟩
257 View
258 Download

Altmetric

Share

Gmail Facebook Twitter LinkedIn More