A case report of pseudoprogression followed by complete remission after proton-beam irradiation for a low-grade glioma in a teenager: the value of dynamic contrast-enhanced MRI - Archive ouverte HAL Access content directly
Journal Articles Radiation Oncology Year : 2010

A case report of pseudoprogression followed by complete remission after proton-beam irradiation for a low-grade glioma in a teenager: the value of dynamic contrast-enhanced MRI

(1) , (2, 3) , (3) , (2, 4) , (5) , (6) , (1) , (1)
1
2
3
4
5
6

Abstract

A fourteen years-old boy was treated post-operatively with proton therapy for a recurrent low-grade oligodendroglioma located in the tectal region. Six months after the end of irradiation (RT), a new enhancing lesion appeared within the radiation fields. To differentiate disease progression from radiation-induced changes, dynamic susceptibility contrast-enhanced (DSCE) MRI was used with a T2* sequence to study perfusion and permeability characteristics simultaneously. Typically, the lesion showed hypoperfusion and hyperpermeability compared to the controlateral normal brain. Without additional treatment but a short course of steroids, the image disappeared over a six months period allowing us to conclude for a pseudo-progression. The patient is alive in complete remission more than 2 years post-RT.
Fichier principal
Vignette du fichier
1748-717X-5-9.pdf (741.81 Ko) Télécharger le fichier
Vignette du fichier
1748-717X-5-9.xml (32.24 Ko) Télécharger le fichier
Origin : Publisher files allowed on an open archive
Format : Other
Loading...

Dates and versions

inserm-00668468 , version 1 (09-02-2012)

Identifiers

Cite

Candice Meyzer, Frédéric Dhermain, Denis Ducreux, Jean-Louis Habrand, Pascale Varlet, et al.. A case report of pseudoprogression followed by complete remission after proton-beam irradiation for a low-grade glioma in a teenager: the value of dynamic contrast-enhanced MRI. Radiation Oncology, 2010, 5 (1), pp.9. ⟨10.1186/1748-717X-5-9⟩. ⟨inserm-00668468⟩
118 View
204 Download

Altmetric

Share

Gmail Facebook Twitter LinkedIn More