R. Garten, C. Davis, C. Russell, B. Shu, S. Lindstrom et al., Antigenic and Genetic Characteristics of Swine-Origin 2009 A(H1N1) Influenza Viruses Circulating in Humans, Science, vol.325, issue.5937, pp.197-201, 2009.
DOI : 10.1126/science.1176225

L. Du, Y. Zhou, and S. Jiang, Research and development of universal influenza vaccines, Microbes and Infection, vol.12, issue.4, pp.280-286
DOI : 10.1016/j.micinf.2010.01.001

S. Neirynck, T. Deroo, X. Saelens, P. Vanlandschoot, W. Jou et al., A universal influenza A vaccine based on the extracellular domain of the M2 protein, Nat Med, vol.5, pp.1157-1163, 1999.

J. Bessa, N. Schmitz, H. Hinton, K. Schwarz, A. Jegerlehner et al., Efficient induction of mucosal and systemic immune responses by virus-like particles administered intranasally: implications for vaccine design, European Journal of Immunology, vol.183, issue.1, pp.114-126, 2008.
DOI : 10.1002/eji.200636959

J. Denis, E. Acosta-ramirez, Y. Zhao, M. Hamelin, I. Koukavica et al., Development of a universal influenza A vaccine based on the M2e peptide fused to the papaya mosaic virus (PapMV) vaccine platform, Vaccine, vol.26, issue.27-28, pp.3395-3403, 2008.
DOI : 10.1016/j.vaccine.2008.04.052

D. Eliasson, E. Bakkouri, K. Schon, K. Ramne, A. Festjens et al., CTA1-M2e-DD: A novel mucosal adjuvant targeted influenza vaccine, Vaccine, vol.26, issue.9, pp.1243-1252, 2008.
DOI : 10.1016/j.vaccine.2007.12.027

M. De-filette, W. Martens, K. Roose, T. Deroo, F. Vervalle et al., An Influenza A Vaccine Based on Tetrameric Ectodomain of Matrix Protein 2, Journal of Biological Chemistry, vol.283, issue.17, pp.11382-11387, 2008.
DOI : 10.1074/jbc.M800650200

J. Huleatt, V. Nakaar, P. Desai, Y. Huang, D. Hewitt et al., Potent immunogenicity and efficacy of a universal influenza vaccine candidate comprising a recombinant fusion protein linking influenza M2e to the TLR5 ligand flagellin, Vaccine, vol.26, issue.2, pp.201-214, 2008.
DOI : 10.1016/j.vaccine.2007.10.062

D. Laddy, J. Yan, M. Kutzler, D. Kobasa, G. Kobinger et al., Heterosubtypic Protection against Pathogenic Human and Avian Influenza Viruses via In Vivo Electroporation of Synthetic Consensus DNA Antigens, PLoS ONE, vol.80, issue.6, p.2517, 2008.
DOI : 10.1371/journal.pone.0002517.t002

J. Fan, X. Liang, M. Horton, H. Perry, M. Citron et al., Preclinical study of influenza virus A M2 peptide conjugate vaccines in mice, ferrets, and rhesus monkeys, Vaccine, vol.22, issue.23-24, pp.2993-3003, 2004.
DOI : 10.1016/j.vaccine.2004.02.021

K. Mozdzanowska, J. Feng, M. Eid, G. Kragol, M. Cudic et al., Induction of influenza type A virus-specific resistance by immunization of mice with a synthetic multiple antigenic peptide vaccine that contains ectodomains of matrix protein 2, Vaccine, vol.21, issue.19-20, pp.2616-2626, 2003.
DOI : 10.1016/S0264-410X(03)00040-9

J. Tam, Synthetic peptide vaccine design: synthesis and properties of a high-density multiple antigenic peptide system., Proceedings of the National Academy of Sciences, vol.85, issue.15, pp.5409-5413, 1988.
DOI : 10.1073/pnas.85.15.5409

C. Wang, D. Looney, M. Li, A. Walfield, J. Ye et al., Long-term high-titer neutralizing activity induced by octameric synthetic HIV-1 antigen, Science, vol.254, issue.5029, pp.285-288, 1991.
DOI : 10.1126/science.1925584

G. Zhao, Y. Lin, L. Du, J. Guan, S. Sun et al., An M2e-based multiple antigenic peptide vaccine protects mice from lethal challenge with divergent H5N1 influenza viruses, Virology Journal, vol.7, issue.1, p.9
DOI : 10.1186/1743-422X-7-9

M. Schotsaert, D. Filette, M. Fiers, and W. , Universal M2 ectodomain-based influenza A vaccines: preclinical and clinical developments, Expert Review of Vaccines, vol.8, issue.4, pp.499-508, 2009.
DOI : 10.1586/erv.09.6

URL : http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2706389

A. Jegerlehner, N. Schmitz, T. Storni, and M. Bachmann, Influenza A Vaccine Based on the Extracellular Domain of M2: Weak Protection Mediated via Antibody-Dependent NK Cell Activity, The Journal of Immunology, vol.172, issue.9, pp.5598-5605, 2004.
DOI : 10.4049/jimmunol.172.9.5598

R. Wang, A. Song, J. Levin, D. Dennis, N. Zhang et al., Therapeutic potential of a fully human monoclonal antibody against influenza A virus M2 protein, Antiviral Research, vol.80, issue.2, pp.168-177, 2008.
DOI : 10.1016/j.antiviral.2008.06.002

W. Liu, P. Zou, J. Ding, Y. Lu, and Y. Chen, Sequence comparison between the extracellular domain of M2 protein human and avian influenza A virus provides new information for bivalent influenza vaccine design, Microbes and Infection, vol.7, issue.2, pp.171-177, 2005.
DOI : 10.1016/j.micinf.2004.10.006

. Zhao, An H5N1 M2e-based multiple antigenic peptide vaccine confers heterosubtypic protection from lethal infection with pandemic 2009 H1N1 virus, Virology Journal, vol.7, issue.1, p.151, 2009.
DOI : 10.1186/1743-422X-7-151

URL : https://hal.archives-ouvertes.fr/inserm-00668214