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Therapeutic activity of two xanthones in a xenograft murine model of human chronic lymphocytic leukemia.

Abstract : BACKGROUND: We previously reported that allanxanthone C and macluraxanthone, two xanthones purified from Guttiferae trees, display in vitro antiproliferative and proapoptotic activities in leukemic cells from chronic lymphocytic leukemia (CLL) and leukemia B cell lines. RESULTS: Here, we investigated the in vivo therapeutic effects of the two xanthones in a xenograft murine model of human CLL, developed by engrafting CD5-transfected chronic leukemia B cells into SCID mice. Treatment of the animals with five daily injections of either allanxanthone C or macluraxanthone resulted in a significant prolongation of their survival as compared to control animals injected with the solvent alone (p = 0.0006 and p = 0.0141, respectively). The same treatment of mice which were not xenografted induced no mortality. CONCLUSION: These data show for the first time the in vivo antileukemic activities of two plant-derived xanthones, and confirm their potential interest for CLL therapy.
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Séverine Loisel, Karine Le Ster, Michèle Meyer, Christian Berthou, Pierre Youinou, et al.. Therapeutic activity of two xanthones in a xenograft murine model of human chronic lymphocytic leukemia.. Journal of Hematology and Oncology, BioMed Central, 2010, 3 (1), pp.49. ⟨10.1186/1756-8722-3-49⟩. ⟨inserm-00668205⟩

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