Safety concern between autologous fat graft, mesenchymal stem cell and osteosarcoma recurrence.

Pierre Perrot 1, 2 Julie Rousseau 1 Anne-Laure Bouffaut 1, 2 Françoise Rédini 1 Elisabeth Cassagnau 3 Frédéric Deschaseaux 4 Marie-Françoise Heymann 1, 3 Dominique Heymann 1 Franck Duteille 1, 2 Valérie Trichet 1 François Gouin 1, 5, 6, *
* Auteur correspondant
1 Physiopathologie de la Résorption Osseuse et Thérapie des Tumeurs Osseuses Primitives
2 Service de Chirurgie Plastique et des Brulés
3 Service d'Anatomie Pathologique
4 EA3855 - Etablissement Français du Sang Centre-Atlantique
5 CHU Nantes - Centre hospitalier universitaire de Nantes
6 Service d'Orthopédie-Traumatologie, Pôle Ostéo-articulaire
Abstract : BACKGROUND: Osteosarcoma is the most common malignant primary bone tumour in young adult treated by neo adjuvant chemotherapy, surgical tumor removal and adjuvant multidrug chemotherapy. For correction of soft tissue defect consecutive to surgery and/or tumor treatment, autologous fat graft has been proposed in plastic and reconstructive surgery. PRINCIPAL FINDINGS: We report here a case of a late local recurrence of osteosarcoma which occurred 13 years after the initial pathology and 18 months after a lipofilling procedure. Because such recurrence was highly unexpected, we investigated the possible relationship of tumor growth with fat injections and with mesenchymal stem/stromal cell like cells which are largely found in fatty tissue. Results obtained in osteosarcoma pre-clinical models show that fat grafts or progenitor cells promoted tumor growth. SIGNIFICANCE: These observations and results raise the question of whether autologous fat grafting is a safe reconstructive procedure in a known post neoplasic context.
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Article dans une revue
PLoS ONE, Public Library of Science, 2010, 5 (6), pp.e10999. 〈10.1371/journal.pone.0010999〉
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Soumis le : mercredi 8 février 2012 - 16:16:08
Dernière modification le : jeudi 5 avril 2018 - 10:36:48
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Pierre Perrot, Julie Rousseau, Anne-Laure Bouffaut, Françoise Rédini, Elisabeth Cassagnau, et al.. Safety concern between autologous fat graft, mesenchymal stem cell and osteosarcoma recurrence.. PLoS ONE, Public Library of Science, 2010, 5 (6), pp.e10999. 〈10.1371/journal.pone.0010999〉. 〈inserm-00667931〉

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