 |
Journal articles
Safety concern between autologous fat graft, mesenchymal stem cell and osteosarcoma recurrence.
Abstract : BACKGROUND: Osteosarcoma is the most common malignant primary bone tumour in young adult treated by neo adjuvant chemotherapy, surgical tumor removal and adjuvant multidrug chemotherapy. For correction of soft tissue defect consecutive to surgery and/or tumor treatment, autologous fat graft has been proposed in plastic and reconstructive surgery. PRINCIPAL FINDINGS: We report here a case of a late local recurrence of osteosarcoma which occurred 13 years after the initial pathology and 18 months after a lipofilling procedure. Because such recurrence was highly unexpected, we investigated the possible relationship of tumor growth with fat injections and with mesenchymal stem/stromal cell like cells which are largely found in fatty tissue. Results obtained in osteosarcoma pre-clinical models show that fat grafts or progenitor cells promoted tumor growth. SIGNIFICANCE: These observations and results raise the question of whether autologous fat grafting is a safe reconstructive procedure in a known post neoplasic context.
https://www.hal.inserm.fr/inserm-00667931
Contributor : D* Heymann <>
Submitted on : Wednesday, February 8, 2012 - 4:16:08 PM
Last modification on : Thursday, July 11, 2019 - 2:10:07 PM
Long-term archiving on: : Monday, May 14, 2012 - 1:19:51 PM
Contributor : D* Heymann <>
Submitted on : Wednesday, February 8, 2012 - 4:16:08 PM
Last modification on : Thursday, July 11, 2019 - 2:10:07 PM
Long-term archiving on: : Monday, May 14, 2012 - 1:19:51 PM
File
journal.pone.0010999.pdf
Publisher files allowed on an open archive