Skip to Main content Skip to Navigation
Journal articles

Noribogaine, but not 18-MC, exhibits similar actions as ibogaine on GDNF expression and ethanol self-administration.

Abstract : Ibogaine is a naturally occurring alkaloid that has been reported to decrease various adverse phenotypes associated with exposure to drugs of abuse and alcohol in human and rodent models. Unfortunately, ibogaine cannot be used as a medication to treat addiction because of severe side effects. Previously, we reported that the desirable actions of ibogaine to reduce self-administration of, and relapse to, alcohol consumption are mediated via the upregulation of the expression of the glial cell line-derived neurotrophic factor (GDNF) in the midbrain ventral tegmental area (VTA), and the consequent activation of the GDNF pathway. The ibogaine metabolite, noribogaine, and a synthetic derivative of ibogaine, 18-Methoxycoronaridine (18-MC), possess a similar anti-addictive profile as ibogaine in rodent models, but without some of its adverse side effects. Here, we determined whether noribogaine and/or 18-MC, like ibogaine, increase GDNF expression, and whether their site of action to reduce alcohol consumption is the VTA. We used SH-SY5Y cells as a cell culture model and found that noribogaine, like ibogaine, but not 18-MC, induces a robust increase in GDNF mRNA levels. Next, we tested the effect of intra-VTA infusion of noribogaine and 18-MC on rat operant alcohol self-administration and found that noribogaine, but not 18-MC, in the VTA decreases responding for alcohol. Together, our results suggest that noribogaine and 18-MC have different mechanisms and sites of action.
Document type :
Journal articles
Complete list of metadatas

Cited literature [8 references]  Display  Hide  Download

https://www.hal.inserm.fr/inserm-00665103
Contributor : Marc Savasta <>
Submitted on : Wednesday, February 1, 2012 - 11:19:17 AM
Last modification on : Wednesday, November 4, 2020 - 2:48:39 PM
Long-term archiving on: : Wednesday, May 2, 2012 - 2:25:48 AM

File

Carnicella-2010-Noribogaine-VA...
Files produced by the author(s)

Identifiers

Collections

Citation

Sebastien Carnicella, Dao-Yao He, Quinn Yowell, Stanley Glick, Dorit Ron. Noribogaine, but not 18-MC, exhibits similar actions as ibogaine on GDNF expression and ethanol self-administration.. Addiction Biology, Wiley, 2010, 15 (4), pp.424-33. ⟨10.1111/j.1369-1600.2010.00251.x⟩. ⟨inserm-00665103⟩

Share

Metrics

Record views

254

Files downloads

510