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[Other actors in the oocyte and follicular growth: The role of microRNAs in the cumulus-oocyte dialog].

S. Moussaddykine 1, 2 Said Assou 1, 2 Hervé Déchaud 3 Samir Hamamah 4, *
* Corresponding author
4 Développement embryonnaire précoce, cellules souches pluripotentes et hépatocytaires
IRB - Institut de recherche en biothérapie, Service de gynécologie-obstétrique et médecine de la reproduction, Cellules souches normales et cancéreuses
Abstract : The good folliculogenesis evolution is fundamental for the obtaining of a competent oocyte, able to lead to pregnancy, once fertilized. During the follicular development, the oocyte is in close contact with surrounding cumulus cells (CCs) to form a cumulus-oocyte complex. The bidirectional exchange between oocyte and contiguous CCs via gap junction communications and paracrine signaling is important for oocyte competence and CCs development. These reciprocal regulations are controlled by some key genes. Recently, it has been demonstrated that these genes are themselves regulated by short RNAs fragments (approximately 22 nucleotides), called microRNAs. The identification and the quantification in the CCs of the microRNAs regulating these genes could promote the development of non invasive tests in order to assess the oocyte quality and its ability to provide embryo with a high implantation potential. This approach could be decisive in the embryo selection to transfer and could avoid the risk of multiple pregnancies by the replacement of a single embryo.
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Submitted on : Tuesday, January 31, 2012 - 9:50:51 AM
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S. Moussaddykine, Said Assou, Hervé Déchaud, Samir Hamamah. [Other actors in the oocyte and follicular growth: The role of microRNAs in the cumulus-oocyte dialog].. Gynécologie Obstétrique & Fertilité, Elsevier Masson, 2012, 40 (3), pp.170-3. ⟨10.1016/j.gyobfe.2011.10.011⟩. ⟨inserm-00664585⟩

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