Optical spectroscopy combined with high-resolution magnetic resonance imaging for digestive wall assessment: endoluminal bimodal probe conception and characterization in vitro, on organic sample and in vivo on a rabbit.

Anoop Ramgolam; Raphaël Sablong; Lionel Lafarge; Hervé Saint-Jalmes; Olivier Beuf

doi:10.1117/1.3646917

Optical spectroscopy combined with high-resolution magnetic resonance imaging for digestive wall assessment: endoluminal bimodal probe conception and characterization in vitro, on organic sample and in vivo on a rabbit.

Anoop Ramgolam ¹ Raphaël Sablong ² Lionel Lafarge ³ Hervé Saint-Jalmes ^{4, 5} Olivier Beuf ¹

1 RMN et optique : De la mesure au biomarqueur

CREATIS - Centre de Recherche en Acquisition et Traitement de l'Image pour la Santé

2 LSP - Laboratoire de Spectrométrie Physique

3 LaMCoS - Laboratoire de Mécanique des Contacts et des Structures [Villeurbanne]

4 CRLCC - CRLCC Eugène Marquis

5 LTSI - Laboratoire Traitement du Signal et de l'Image

Abstract : Colorectal cancer is a major health issue worldwide. Conventional white light endoscopy (WLE) coupled to histology is considered as the gold standard today and is the most widespread technique used for colorectal cancer diagnosis. However, during the early stages, colorectal cancer is very often characterized by flat adenomas which develop just underneath the mucosal surface. The use of WLE, which is heavily based on the detection of morphological changes, becomes quite delicate due to subtle or quasi-invisible morphological changes of the colonic lining. Several techniques are currently being investigated in the scope of providing new tools that would allow such a diagnostic or assist actual techniques in so doing. We hereby present a novel technique where high spatial resolution MRI is combined with autofluorescence and reflectance spectroscopy in a bimodal endoluminal probe to extract morphological data and biochemical information, respectively. The design and conception of the endoluminal probe are detailed and the promising preliminary results obtained in vitro (home-built phantom containing eosin and rhodamine B), on an organic sample (the kiwi fruit) and in vivo on a rabbit are presented and discussed.

Keywords : Water Absorption Magnetic resonance imaging Optical spectroscopy Reflectivity Colon Luminescence Distortion

Type de document :

Article dans une revue

Journal of Biomedical Optics, Society of Photo-optical Instrumentation Engineers, 2011, 16 (11), pp.117005. 〈10.1117/1.3646917〉

Domaine :

Sciences du Vivant [q-bio] / Ingénierie biomédicale

Liste complète des métadonnées

http://www.hal.inserm.fr/inserm-00664036
Contributeur : Lotfi Senhadji <>
Soumis le : samedi 28 janvier 2012 - 11:36:01
Dernière modification le : mardi 11 septembre 2018 - 11:00:02

Optical spectroscopy combined with high-resolution magnetic resonance imaging for digestive wall assessment: endoluminal bimodal probe conception and characterization in vitro, on organic sample and in vivo on a rabbit.

Identifiants

Collections

Citation

Exporter

Métriques

999

Contact

Optical spectroscopy combined with high-resolution magnetic resonance imaging for digestive wall assessment: endoluminal bimodal probe conception and characterization in vitro, on organic sample and in vivo on a rabbit.

Identifiants

Collections

Citation

Exporter

Partager

Métriques

999

Contact