Rhinal-hippocampal interactions during déjà vu.

Fabrice Bartolomei 1, 2, * Emmanuel Barbeau 3 Trung Nguyen 1 Aileen Mcgonigal 1, 2 Jean Régis 1, 4 Patrick Chauvel 1, 2 Fabrice Wendling 5
* Auteur correspondant
1 Epilepsies, Lesions Cerebrales et Systemes Neuraux de la Cognition
2 Service de Neurophysiologie Clinique
3 CERCO - Centre de recherche cerveau et cognition
4 Service de neurochirurgie fontionnelle et stéréotaxique
5 LTSI - Laboratoire Traitement du Signal et de l'Image
Abstract : OBJECTIVE: The phenomenon of 'déjà vu' is caused by acute disturbance of mnemonic systems of the medial temporal lobe (MTL). In epileptic patients investigated with intracerebral electrodes, déjà vu can be more readily induced by stimulation of the rhinal cortices (RCs) than the hippocampus (H). Whether déjà vu results from acute dysfunction of the familiarity system alone (sustained by RC) or from more extensive involvement of the MTL region (including H) is debatable. METHODS: We analysed the synchronisation of intracerebral electroencephalography (EEG) signals recorded from RC, H and amygdala (A) in epileptic patients in whom déjà vu was induced by electrical stimulation. EEG signal correlations (between signals from RC, A and H) were evaluated using a nonlinear regression. RESULTS: In comparison with RC stimulations that did not lead to déjà vu (DV-), stimulations triggering déjà vu (DV+) were associated with increased broadband EEG correlation (p=0.01). Changes in correlations were significantly different in the theta band for RC-A (p=0.007) and RC-H (p=0.01) and in the beta band for RC-H (p=0.001) interactions. CONCLUSION: Déjà vu is associated with increased EEG signal correlation between MTL structures. SIGNIFICANCE: Results are in favour of a mechanism involving transient co-operation between various MTL structures, not limited to RC alone.
Type de document :
Article dans une revue
Clinical Neurophysiology, Elsevier, 2012, 123 (3), pp.489-495. 〈10.1016/j.clinph.2011.08.012〉
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http://www.hal.inserm.fr/inserm-00664030
Contributeur : Lotfi Senhadji <>
Soumis le : samedi 28 janvier 2012 - 10:52:35
Dernière modification le : mardi 11 septembre 2018 - 15:18:36

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LTSI | CERCO | UNIV-AMU | UNIV-TLSE3 | UNIV-RENNES

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Fabrice Bartolomei, Emmanuel Barbeau, Trung Nguyen, Aileen Mcgonigal, Jean Régis, et al.. Rhinal-hippocampal interactions during déjà vu.. Clinical Neurophysiology, Elsevier, 2012, 123 (3), pp.489-495. 〈10.1016/j.clinph.2011.08.012〉. 〈inserm-00664030〉

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