E box motifs as mediators of proviral latency of human retroviruses. - Inserm - Institut national de la santé et de la recherche médicale Access content directly
Journal Articles Retrovirology Year : 2009

E box motifs as mediators of proviral latency of human retroviruses.


The palindromic sequence motifs (CANNTG) known as E boxes are considered as binding sites for the basic helix-loop-helix (bHLH) class of DNA-binding proteins. Their presence has been reported in the long terminal repeats (LTR) of the HIV-1 and HTLV-1 proviruses. Their close proximity with the TATA region of both LTRs indicates that the bHLH proteins may act as important regulators of the function of proviral transcription. Indeed, observations on HIV-1 and recent results on HTLV-1 underline that these E boxes may be critically involved in the regulation of the proviral transcription of these human retroviruses. Indeed, of the two E boxes flanking the TATA sequences of the HIV-1 provirus, the 3' E box has been implicated in the transcriptional inhibition of viral gene expression. Such a role might also be played by the unique 5' E box present in the HTLV-1 LTR. In both cases, the expression of tissue-specfic bHLH proteins, like TAL1 might counteract the inhibitory effect exerted by E box proteins, thereby increasing proviral transcription. Finally, a phylogenetic study encompassing several subtypes of these two human retroviruses underlines that these E box motifs have recently appeared in the proviral LTRs and may be considered as potential mediators in the establishment of proviral latency.
Fichier principal
Vignette du fichier
1742-4690-6-81.pdf (520.4 Ko) Télécharger le fichier
1742-4690-6-81.xml (54.52 Ko) Télécharger le fichier
Origin : Publisher files allowed on an open archive
Format : Other

Dates and versions

inserm-00663933 , version 1 (27-01-2012)



Jean-Michel Terme, Sébastien Calvignac, Madeleine Duc Dodon, Louis Gazzolo, Albert Jordan. E box motifs as mediators of proviral latency of human retroviruses.. Retrovirology, 2009, 6 (1), pp.81. ⟨10.1186/1742-4690-6-81⟩. ⟨inserm-00663933⟩
100 View
267 Download



Gmail Facebook Twitter LinkedIn More