D. Angus, W. Linde-zwirble, J. Lidicker, G. Clermont, J. Carcillo et al., Epidemiology of severe sepsis in the United States: Analysis of incidence, outcome, and associated costs of care, Critical Care Medicine, vol.29, issue.7, pp.1303-1310, 2001.
DOI : 10.1097/00003246-200107000-00002

C. Brun-buisson, P. Meshaka, P. Pinton, B. Vallet, . Episepsis-study et al., EPISEPSIS: a reappraisal of the epidemiology and outcome of severe sepsis in French intensive care units, Intensive Care Med, vol.30, pp.580-588, 2004.

R. Hotchkiss and I. Karl, The Pathophysiology and Treatment of Sepsis, New England Journal of Medicine, vol.348, issue.2, pp.138-150, 2003.
DOI : 10.1056/NEJMra021333

R. Hotchkiss, P. Swanson, J. Cobb, A. Jacobson, T. Buchman et al., Apoptosis in lymphoid and parenchymal cells during sepsis, Critical Care Medicine, vol.25, issue.8, pp.1298-1307, 1997.
DOI : 10.1097/00003246-199708000-00015

S. Sakaguchi, M. Ono, R. Setoguchi, H. Yagi, S. Hori et al., Foxp3+CD25+CD4+ natural regulatory T cells in dominant self-tolerance and autoimmune disease, Immunological Reviews, vol.25, issue.1, pp.8-27, 2006.
DOI : 10.1111/j.0105-2896.2005.00248.x

Z. Fehérvari and S. Sakaguchi, CD4+ Tregs and immune control, Journal of Clinical Investigation, vol.114, issue.9, pp.1209-1217, 2004.
DOI : 10.1172/JCI200423395

E. Shevach, Regulatory T Cells in Autoimmmunity, Annual Review of Immunology, vol.18, issue.1, pp.423-449, 2000.
DOI : 10.1146/annurev.immunol.18.1.423

D. Vignali, L. Collison, and C. Workman, How regulatory T cells work, Nature Reviews Immunology, vol.178, issue.7, pp.523-532, 2008.
DOI : 10.1038/nri2343

G. Monneret, F. Venet, A. Pachot, and A. Lepape, Monitoring immune dysfunctions in the septic patient: a new skin for the old ceremony, Mol Med, vol.14, pp.64-78, 2008.

F. Venet, A. Pachot, A. Debard, J. Bohé, J. Bienvenu et al., Increased percentage of CD4+CD25+ regulatory T cells during septic shock is due to the decrease of CD4+CD25??? lymphocytes, Critical Care Medicine, vol.32, issue.11, pp.2329-2331, 2004.
DOI : 10.1097/01.CCM.0000145999.42971.4B

J. Heuer, T. Zhang, J. Zhao, C. Ding, M. Cramer et al., Adoptive Transfer of In Vitro-Stimulated CD4+CD25+ Regulatory T Cells Increases Bacterial Clearance and Improves Survival in Polymicrobial Sepsis, The Journal of Immunology, vol.174, issue.11, pp.7141-7146, 2005.
DOI : 10.4049/jimmunol.174.11.7141

P. Scumpia, M. Delano, K. Kelly, O. Malley, K. Efron et al., Increased Natural CD4+CD25+ Regulatory T Cells and Their Suppressor Activity Do Not Contribute to Mortality in Murine Polymicrobial Sepsis, The Journal of Immunology, vol.177, issue.11, pp.7943-7949, 2006.
DOI : 10.4049/jimmunol.177.11.7943

F. Venet, C. Chung, H. Kherouf, A. Geeraert, C. Malcus et al., Increased circulating regulatory T cells (CD4+CD25+CD127???) contribute to lymphocyte anergy in septic shock patients, Intensive Care Medicine, vol.71, issue.4, pp.678-686, 2009.
DOI : 10.1007/s00134-008-1337-8

R. Bone, R. Balk, F. Cerra, R. Dellinger, A. Fein et al., Definitions for Sepsis and Organ Failure and Guidelines for the Use of Innovative Therapies in Sepsis, The ACCP/SCCM Consensus Conference Committee, pp.1644-1655, 1992.
DOI : 10.1378/chest.101.6.1644

M. Antonelli, M. Levy, P. Andrews, J. Chastre, L. Hudson et al., Hemodynamic monitoring in shock and implications for management, International consensus conference, pp.27-28575, 2006.
DOI : 10.1007/s00134-007-0531-4

W. Mccabe and G. Jackson, Gram-Negative Bacteremia, Archives of Internal Medicine, vol.110, issue.6, pp.845-847, 1962.
DOI : 10.1001/archinte.1962.03620240029006

L. Gall, J. Lemeshow, S. Saulnier, and F. , A new Simplified Acute Physiology Score (SAPS II) based on a European/North American multicenter study, JAMA, vol.271, pp.2957-2963, 1993.

J. Vincent, A. De-mendonça, F. Cantraine, R. Moreno, J. Takala et al., Use of the SOFA score to assess the incidence of organ dysfunction/failure in intensive care units, Critical Care Medicine, vol.26, issue.11, pp.1793-1800, 1998.
DOI : 10.1097/00003246-199811000-00016

G. Monneret, A. Debard, F. Venet, J. Bohe, O. Hequet et al., Marked elevation of human circulating CD4+CD25+ regulatory T cells in sepsis-induced immunoparalysis, Critical Care Medicine, vol.31, issue.7, pp.2068-2071, 2003.
DOI : 10.1097/01.CCM.0000069345.78884.0F

A. Oberholzer, C. Oberholzer, and L. Moldawer, SEPSIS SYNDROMES: UNDERSTANDING THE ROLE OF INNATE AND ACQUIRED IMMUNITY, Shock, vol.16, issue.2, pp.83-96, 2001.
DOI : 10.1097/00024382-200116020-00001

E. Giamarellos-bourboulis, T. Tsaganos, E. Spyridaki, M. Mouktaroudi, D. Plachouras et al., Early changes of CD4-positive lymphocytes and NK cells in patients with severe Gram-negative sepsis, Critical Care, vol.10, issue.6, p.166, 2006.
DOI : 10.1186/cc5111

. Hein, 1186/cc8876 Cite this article as The relationship between CD4 + CD25 + CD127 -regulatory T cells and inflammatory response and outcome during shock states, Critical Care, vol.14, pp.10-19, 2010.