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Molecular mechanisms of HIV-1 persistence in the monocyte-macrophage lineage.

Abstract : The introduction of the highly active antiretroviral therapy (HAART) has greatly improved survival. However, these treatments fail to definitively cure the patients and unveil the presence of quiescent HIV-1 reservoirs like cells from monocyte-macrophage lineage. A purge, or at least a significant reduction of these long lived HIV-1 reservoirs will be needed to raise the hope of the viral eradication. This review focuses on the molecular mechanisms responsible for viral persistence in cells of the monocyte-macrophage lineage. Controversy on latency and/or cryptic chronic replication will be specifically evoked. In addition, since HIV-1 infected monocyte-macrophage cells appear to be more resistant to apoptosis, this obstacle to the viral eradication will be discussed. Understanding the intimate mechanisms of HIV-1 persistence is a prerequisite to devise new and original therapies aiming to achieve viral eradication.
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Valentin Le Douce, Georges Herbein, Olivier Rohr, Christian Schwartz. Molecular mechanisms of HIV-1 persistence in the monocyte-macrophage lineage.. Retrovirology, BioMed Central, 2010, 7 (1), pp.32. ⟨10.1186/1742-4690-7-32⟩. ⟨inserm-00663900⟩



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