Skip to Main content Skip to Navigation
Journal articles

Molecular mechanisms of HIV-1 persistence in the monocyte-macrophage lineage.

Abstract : The introduction of the highly active antiretroviral therapy (HAART) has greatly improved survival. However, these treatments fail to definitively cure the patients and unveil the presence of quiescent HIV-1 reservoirs like cells from monocyte-macrophage lineage. A purge, or at least a significant reduction of these long lived HIV-1 reservoirs will be needed to raise the hope of the viral eradication. This review focuses on the molecular mechanisms responsible for viral persistence in cells of the monocyte-macrophage lineage. Controversy on latency and/or cryptic chronic replication will be specifically evoked. In addition, since HIV-1 infected monocyte-macrophage cells appear to be more resistant to apoptosis, this obstacle to the viral eradication will be discussed. Understanding the intimate mechanisms of HIV-1 persistence is a prerequisite to devise new and original therapies aiming to achieve viral eradication.
Document type :
Journal articles
Complete list of metadatas

Cited literature [180 references]  Display  Hide  Download

https://www.hal.inserm.fr/inserm-00663900
Contributor : Ed. Bmc <>
Submitted on : Friday, January 27, 2012 - 5:15:01 PM
Last modification on : Tuesday, October 27, 2020 - 2:34:41 PM
Long-term archiving on: : Saturday, April 28, 2012 - 2:41:53 AM

Files

1742-4690-7-32.pdf
Publisher files allowed on an open archive

Identifiers

Collections

Citation

Valentin Le Douce, Georges Herbein, Olivier Rohr, Christian Schwartz. Molecular mechanisms of HIV-1 persistence in the monocyte-macrophage lineage.. Retrovirology, BioMed Central, 2010, 7 (1), pp.32. ⟨10.1186/1742-4690-7-32⟩. ⟨inserm-00663900⟩

Share

Metrics

Record views

439

Files downloads

1431