The macrophage in HIV-1 infection: from activation to deactivation?

Abstract : Macrophages play a crucial role in innate and adaptative immunity in response to microorganisms and are an important cellular target during HIV-1 infection. Recently, the heterogeneity of the macrophage population has been highlighted. Classically activated or type 1 macrophages (M1) induced in particular by IFN-gamma display a pro-inflammatory profile. The alternatively activated or type 2 macrophages (M2) induced by Th-2 cytokines, such as IL-4 and IL-13 express anti-inflammatory and tissue repair properties. Finally IL-10 has been described as the prototypic cytokine involved in the deactivation of macrophages (dM). Since the capacity of macrophages to support productive HIV-1 infection is known to be modulated by cytokines, this review shows how modulation of macrophage activation by cytokines impacts the capacity to support productive HIV-1 infection. Based on the activation status of macrophages we propose a model starting with M1 classically activated macrophages with accelerated formation of viral reservoirs in a context of Th1 and proinflammatory cytokines. Then IL-4/IL-13 alternatively activated M2 macrophages will enter into the game that will stop the expansion of the HIV-1 reservoir. Finally IL-10 deactivation of macrophages will lead to immune failure observed at the very late stages of the HIV-1 disease.
Type de document :
Article dans une revue
Retrovirology, BioMed Central, 2010, 7 (1), pp.33. 〈10.1186/1742-4690-7-33〉
Liste complète des métadonnées

Littérature citée [175 références]  Voir  Masquer  Télécharger
Contributeur : Ed. Bmc <>
Soumis le : vendredi 27 janvier 2012 - 17:14:54
Dernière modification le : vendredi 30 mars 2018 - 16:00:02
Document(s) archivé(s) le : lundi 19 novembre 2012 - 15:16:01


Fichiers éditeurs autorisés sur une archive ouverte




Georges Herbein, Audrey Varin. The macrophage in HIV-1 infection: from activation to deactivation?. Retrovirology, BioMed Central, 2010, 7 (1), pp.33. 〈10.1186/1742-4690-7-33〉. 〈inserm-00663899〉



Consultations de la notice


Téléchargements de fichiers