Skip to Main content Skip to Navigation
Journal articles

Comparison of albicans vs. non-albicans candidemia in French intensive care units.

Abstract : INTRODUCTION: Candidemia raises numerous therapeutic issues for intensive care physicians. Epidemiological data that could guide the choice of initial therapy are still required. This analysis sought to compare the characteristics of intensive care unit (ICU) patients with candidemia due to non-albicans Candida species with those of ICU patients with candidemia due to Candida albicans. METHODS: A prospective, observational, multicenter, French study was conducted from October 2005 to May 2006. Patients exhibiting candidemia developed during ICU stay and exclusively due either to one or more non-albicans Candida species or to C. albicans were selected. The data collected included patient characteristics on ICU admission and at the onset of candidemia. RESULTS: Among the 136 patients analyzed, 78 (57.4%) had candidemia caused by C. albicans. These patients had earlier onset of infection (11.1 +/- 14.2 days after ICU admission vs. 17.4 +/- 17.7, p = 0.02), higher severity scores on ICU admission (SOFA: 10.4 +/- 4.7 vs. 8.6 +/- 4.6, p = 0.03; SAPS II: 57.4 +/- 22.8 vs. 48.7 +/- 15.5, P = 0.015), and were less often neutropenic (2.6% vs. 12%, p = 0.04) than patients with candidemia due to non-albicans Candida species. CONCLUSIONS: Although patients infected with Candida albicans differed from patients infected with non-albicans Candida species for a few characteristics, no clinical factor appeared pertinent enough to guide the choice of empirical antifungal therapy in ICU.
Document type :
Journal articles
Complete list of metadatas

Cited literature [17 references]  Display  Hide  Download

https://www.hal.inserm.fr/inserm-00663894
Contributor : Ed. Bmc <>
Submitted on : Friday, January 27, 2012 - 5:14:36 PM
Last modification on : Wednesday, August 19, 2020 - 11:17:02 AM
Long-term archiving on: : Saturday, April 28, 2012 - 2:41:26 AM

Files

cc9033.pdf
Publisher files allowed on an open archive

Identifiers

Citation

Olivier Leroy, Jean-Paul Mira, Philippe Montravers, Jean-Pierre Gangneux, Olivier Lortholary. Comparison of albicans vs. non-albicans candidemia in French intensive care units.. Critical Care, BioMed Central, 2010, 14 (3), pp.R98. ⟨10.1186/cc9033⟩. ⟨inserm-00663894⟩

Share

Metrics

Record views

750

Files downloads

1304