Retroviral matrix and lipids, the intimate interaction. - Inserm - Institut national de la santé et de la recherche médicale Accéder directement au contenu
Article Dans Une Revue Retrovirology Année : 2011

Retroviral matrix and lipids, the intimate interaction.

Elise Hamard-Peron
  • Fonction : Auteur
  • PersonId : 919093
Delphine Muriaux
  • Fonction : Auteur correspondant
  • PersonId : 915603

Connectez-vous pour contacter l'auteur

Résumé

Retroviruses are enveloped viruses that assemble on the inner leaflet of cellular membranes. Improving biophysical techniques has recently unveiled many molecular aspects of the interaction between the retroviral structural protein Gag and the cellular membrane lipids. This interaction is driven by the N-terminal matrix domain of the protein, which probably undergoes important structural modifications during this process, and could induce membrane lipid distribution changes as well. This review aims at describing the molecular events occurring during MA-membrane interaction, and pointing out their consequences in terms of viral assembly. The striking conservation of the matrix membrane binding mode among retroviruses indicates that this particular step is most probably a relevant target for antiviral research.
Fichier principal
Vignette du fichier
1742-4690-8-15.pdf (1.21 Mo) Télécharger le fichier
1742-4690-8-15.xml (149.13 Ko) Télécharger le fichier
Origine : Fichiers éditeurs autorisés sur une archive ouverte
Format : Autre

Dates et versions

inserm-00663858 , version 1 (27-01-2012)

Identifiants

Citer

Elise Hamard-Peron, Delphine Muriaux. Retroviral matrix and lipids, the intimate interaction.. Retrovirology, 2011, 8 (1), pp.15. ⟨10.1186/1742-4690-8-15⟩. ⟨inserm-00663858⟩
61 Consultations
155 Téléchargements

Altmetric

Partager

Gmail Facebook X LinkedIn More