Abstract : To confirm, among HIV1-infected patients, data from in vitro studies showing that antiretroviral therapies (ART) induce an accelerated aging through the same mechanism than genetic laminopathies (progeria) and «physiological » aging, i.e. through the synthesis and persistence of farnesylated prelamin A. The perspective is to minimize ART side effects using the same drug combination yet given to treat progeria children in Marseille.
https://www.hal.inserm.fr/inserm-00663755 Contributor : Ed. BMCConnect in order to contact the contributor Submitted on : Friday, January 27, 2012 - 2:22:16 PM Last modification on : Thursday, October 21, 2021 - 3:59:00 AM Long-term archiving on: : Saturday, April 28, 2012 - 2:32:27 AM
Pierre Cau. Progeria, a model for accelerated aging exhibited by HIV patients?. 16th International Symposium on HIV and Emerging Infectious Diseases, ISHEID, Mar 2010, Marseille, France. pp.I29. ⟨inserm-00663755⟩