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Progeria, a model for accelerated aging exhibited by HIV patients?

Abstract : To confirm, among HIV1-infected patients, data from in vitro studies showing that antiretroviral therapies (ART) induce an accelerated aging through the same mechanism than genetic laminopathies (progeria) and «physiological » aging, i.e. through the synthesis and persistence of farnesylated prelamin A. The perspective is to minimize ART side effects using the same drug combination yet given to treat progeria children in Marseille.
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https://www.hal.inserm.fr/inserm-00663755
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Submitted on : Friday, January 27, 2012 - 2:22:16 PM
Last modification on : Wednesday, August 19, 2020 - 12:08:08 PM
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Pierre Cau. Progeria, a model for accelerated aging exhibited by HIV patients?. 16th International Symposium on HIV and Emerging Infectious Diseases, ISHEID, Mar 2010, Marseille, France. pp.I29. ⟨inserm-00663755⟩

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