Progeria, a model for accelerated aging exhibited by HIV patients?
Abstract
To confirm, among HIV1-infected patients, data from in vitro studies showing that antiretroviral therapies (ART) induce an accelerated aging through the same mechanism than genetic laminopathies (progeria) and «physiological » aging, i.e. through the synthesis and persistence of farnesylated prelamin A. The perspective is to minimize ART side effects using the same drug combination yet given to treat progeria children in Marseille.
Domains
Infectious diseases
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