OrthoInspector: comprehensive orthology analysis and visual exploration. - Inserm - Institut national de la santé et de la recherche médicale Access content directly
Journal Articles BMC Bioinformatics Year : 2011

OrthoInspector: comprehensive orthology analysis and visual exploration.


BACKGROUND: The accurate determination of orthology and inparalogy relationships is essential for comparative sequence analysis, functional gene annotation and evolutionary studies. Various methods have been developed based on either simple blast all-versus-all pairwise comparisons and/or time-consuming phylogenetic tree analyses. RESULTS: We have developed OrthoInspector, a new software system incorporating an original algorithm for the rapid detection of orthology and inparalogy relations between different species. In comparisons with existing methods, OrthoInspector improves detection sensitivity, with a minimal loss of specificity. In addition, several visualization tools have been developed to facilitate in-depth studies based on these predictions. The software has been used to study the orthology/in-paralogy relationships for a large set of 940,855 protein sequences from 59 different eukaryotic species. CONCLUSION: OrthoInspector is a new software system for orthology/paralogy analysis. It is made available as an independent software suite that can be downloaded and installed for local use. Command line querying facilitates the integration of the software in high throughput processing pipelines and a graphical interface provides easy, intuitive access to results for the non-expert.
Fichier principal
Vignette du fichier
1471-2105-12-11.pdf (1.01 Mo) Télécharger le fichier
1471-2105-12-11-S1.XLS (22 Ko) Télécharger le fichier
1471-2105-12-11-S2.PDF (121.52 Ko) Télécharger le fichier
1471-2105-12-11-S3.PDF (121.29 Ko) Télécharger le fichier
1471-2105-12-11-S4.XLS (111 Ko) Télécharger le fichier
1471-2105-12-11.xml (76.52 Ko) Télécharger le fichier
Origin : Publisher files allowed on an open archive
Format : Other
Format : Other
Format : Other
Format : Other
Format : Other

Dates and versions

inserm-00663697 , version 1 (27-01-2012)



Benjamin Linard, Julie Thompson, Olivier Poch, Odile Lecompte. OrthoInspector: comprehensive orthology analysis and visual exploration.. BMC Bioinformatics, 2011, 12 (1), pp.11. ⟨10.1186/1471-2105-12-11⟩. ⟨inserm-00663697⟩
330 View
352 Download



Gmail Facebook Twitter LinkedIn More