High levels of circulating leukocyte microparticles are associated with better outcome in acute respiratory distress syndrome. - Inserm - Institut national de la santé et de la recherche médicale Access content directly
Journal Articles Critical Care Year : 2011

High levels of circulating leukocyte microparticles are associated with better outcome in acute respiratory distress syndrome.

Abstract

INTRODUCTION: The current study has addressed the presence and the cellular origin of microparticles (MP) isolated from bronchoalveolar lavage (BAL) fluid and from blood samples from patients with acute respiratory distress syndrome (ARDS). Their prognostic interest was also investigated. METHODS: Fifty-two patients were included within the first 24 hours of ARDS. They were compared to spontaneous breathing (SB) and ventilated control (VC) groups. Bronchoalveolar lavage (BAL) and blood samples were obtained on Day 1 and Day 3 in an ARDS group. Leukocyte microparticles (LeuMP), neutrophil microparticles (NeuMP), endothelial microparticles (EMP), and platelet microparticles (PMP) were measured in arterial blood and in BAL samples by flow cytometry. Mortality from all causes was recorded at Day 28. RESULTS: All MP subpopulations were detected in BAL. However, only LeuMP and NeuMP were elevated in ARDS patients compared to the SB group (P = 0.002 for both). Among ARDS patients, higher levels of LeuMP were detected in blood (Day 1) and in BAL (Day 3) in survivors as compared with the non survivors. Circulating LeuMP >60 elements/microliter detectable on Day 1 of ARDS, was associated with a higher survival rate (odds ratio, 5.26; 95% confidence interval, 1.10 to 24.99; P = 0.037). CONCLUSIONS: The identification of the cellular origin of microparticles at the onset of ARDS has identified LeuMP as a biomarker of prognostic significance. The higher levels of LeuMP in survivors could be associated with a protective role of this MP subpopulation. This hypothesis needs further investigations.
Fichier principal
Vignette du fichier
cc9978.pdf (336 Ko) Télécharger le fichier
cc9978.xml (73.53 Ko) Télécharger le fichier
Origin : Publisher files allowed on an open archive
Format : Other
Loading...

Dates and versions

inserm-00663691 , version 1 (27-01-2012)

Identifiers

Cite

Christophe Guervilly, Romaric Lacroix, Jean-Marie Forel, Antoine Roch, Laurence Camoin-Jau, et al.. High levels of circulating leukocyte microparticles are associated with better outcome in acute respiratory distress syndrome.. Critical Care, 2011, 15 (1), pp.R31. ⟨10.1186/cc9978⟩. ⟨inserm-00663691⟩
198 View
221 Download

Altmetric

Share

Gmail Facebook Twitter LinkedIn More