Association pour la Recherche et le Développement de Moyens de Lutte contre les Maladies Neurodégénératives to J.P.L and by Deutsche Forschungsgemeinschaft (KFO142) to ACL. We acknowledge the skilful technical assistance of Marie-José Ruivo, Olivier Schandène and Annie Picchinenna. LD is supported by a grant from the " agence nationale de la recherche, ANR) (young researcher program ,
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