Cardiac troponin and skeletal muscle oxygenation in severe post-partum haemorrhage - Inserm - Institut national de la santé et de la recherche médicale Accéder directement au contenu
Article Dans Une Revue Critical Care Année : 2009

Cardiac troponin and skeletal muscle oxygenation in severe post-partum haemorrhage

Résumé

Introduction
Cardiac troponin has been shown to be elevated in one-half of the parturients admitted for post-partum haemorrhage. The purpose of the study was to assess whether increased cardiac troponin was associated with a simultaneous alteration in haemoglobin tissue oxygen saturation in peripheral muscles in post-partum haemorrhage.
Methods
Tissue haemoglobin oxygen saturation of thenar eminence muscle (StO2) was measured via near-infrared spectroscopy technology. Two sets of StO2 parameters (both isolated baseline and during forearm ischaemia-reperfusion tests) were collected at two time points: upon intensive care unit admission and prior to intensive care unit discharge. Comparisons were performed using Wilcoxon paired tests, and univariate associations were assessed using logistic regression model and Wald tests.
Results
The 42 studied parturients, admitted for post-partum haemorrhage, had clinical and biological signs of severe blood loss. Initial cardiac troponin I was increased in 24/42 parturients (0.43 ± 0.60 μrg/l). All measured parameters of muscular haemoglobin oxygen saturation, including Srecovery, were also altered at admission and improved together with improved haemodynamics, when bleeding was controlled. Multivariate analysis showed that muscular Srecovery <3%/second at admission was strongly associated with increased cardiac troponin.
Conclusions
Our study confirmed the high incidence of increased cardiac troponin, and demonstrated the simultaneous impairment in the reserve of oxygen delivery to peripheral muscles in parturients admitted for severe post-partum haemorrhage.
Fichier principal
Vignette du fichier
cc8006.pdf (186.19 Ko) Télécharger le fichier
cc8006.xml (75.31 Ko) Télécharger le fichier
Origine : Fichiers éditeurs autorisés sur une archive ouverte
Format : Autre
Loading...

Dates et versions

inserm-00663557 , version 1 (27-01-2012)

Identifiants

Citer

Laurent Heyer, Alexandre Mebazaa, Etienne Gayat, Matthieu Resche-Rigon, Christophe Rabuel, et al.. Cardiac troponin and skeletal muscle oxygenation in severe post-partum haemorrhage. Critical Care, 2009, 13 (Suppl 5), pp.S8. ⟨10.1186/cc8006⟩. ⟨inserm-00663557⟩

Collections

INSERM UNIV-PARIS7
180 Consultations
3213 Téléchargements

Altmetric

Partager

Gmail Facebook X LinkedIn More