In vivo MRI assessment of permanent middle cerebral artery occlusion by electrocoagulation: pitfalls of procedure

Permanent middle cerebral artery (MCA) occlusion (pMCAO) by electrocoagulation is a commonly used model but with potential traumatic lesions. Early MRI monitoring may assess pMCAO for non-specific brain damage. The surgical steps of pMCAO were evaluated for traumatic cerebral injury in 22 Swiss mice using diffusion and T2-weighted MRI (7T) performed within 1 h and 24 h after surgery. Temporal muscle cauterization without MCA occlusion produced an early T2 hyperintensity mimicking an infarct. No lesion was visible after temporal muscle incision or craniotomy. Early MRI monitoring is useful to identify non-specific brain injury that could hamper neuroprotective drugs assessment.

Domains

Life Sciences [q-bio] Human health and pathology Cardiology and cardiovascular system Life Sciences [q-bio] Neurons and Cognition [q-bio.NC] Neurobiology

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https://www.hal.inserm.fr/inserm-00663532

Submitted on : Friday, January 27, 2012-1:03:18 PM

Last modification on : Thursday, September 1, 2022-3:57:49 AM

Long-term archiving on: Monday, November 19, 2012-2:55:09 PM

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inserm-00663532 , version 1 (27-01-2012)

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HAL Id : inserm-00663532 , version 1
DOI : 10.1186/2040-7378-2-4
PUBMED : 20298536

Cite

Fabien Chauveau, Samir Moucharrafie, Marlène Wiart, Jean-Christophe Brisset, Yves Berthezène, et al.. In vivo MRI assessment of permanent middle cerebral artery occlusion by electrocoagulation: pitfalls of procedure. Experimental & Translational Stroke Medicine, 2010, 2 (1), pp.4. ⟨10.1186/2040-7378-2-4⟩. ⟨inserm-00663532⟩

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