N. Roeleveld, G. Zielhuis, and F. Gabreels, The prevalence of mental retardation: a critical review of recent literature, Developmental Medicine & Child Neurology, vol.22, issue.suppl, pp.125-132, 1997.
DOI : 10.1111/j.1469-8749.1997.tb07395.x

H. Leonard and X. Wen, The epidemiology of mental retardation: Challenges and opportunities in the new millennium, Mental Retardation and Developmental Disabilities Research Reviews, vol.42, issue.3, pp.117-134, 2002.
DOI : 10.1002/mrdd.10031

M. Dierssen and G. Ramakers, Dendritic pathology in mental retardation: from molecular genetics to neurobiology, Genes, Brain and Behavior, vol.17, issue.2, pp.48-60, 2006.
DOI : 10.1111/j.1601-183X.2006.00224.x

A. Strobel, G. Dreisbach, J. Muller, T. Goschke, B. Brocke et al., Genetic Variation of Serotonin Function and Cognitive Control, J Cogn Neurosci, 2007.

P. Whitaker-azmitia, Serotonin and brain development: role in human developmental diseases, Brain Research Bulletin, vol.56, issue.5, pp.479-485, 2001.
DOI : 10.1016/S0361-9230(01)00615-3

A. Persico, E. Mengual, R. Moessner, F. Hall, R. Revay et al., Barrel pattern formation requires serotonin uptake by thalamocortical afferents, and not vesicular monoamine release, J Neurosci, vol.21, pp.6862-6873, 2001.

P. Gaspar, O. Cases, and L. Maroteaux, The developmental role of serotonin: news from mouse molecular genetics, Nature Reviews Neuroscience, vol.17, issue.12, pp.1002-1012, 2003.
DOI : 10.1038/nrn1256

URL : https://hal.archives-ouvertes.fr/hal-01274960

C. Wellman, A. Izquierdo, J. Garrett, K. Martin, J. Carroll et al., Impaired Stress-Coping and Fear Extinction and Abnormal Corticolimbic Morphology in Serotonin Transporter Knock-Out Mice, Journal of Neuroscience, vol.27, issue.3, pp.684-691, 2007.
DOI : 10.1523/JNEUROSCI.4595-06.2007

L. Mamounas, C. Altar, M. Blue, D. Kaplan, L. Tessarollo et al., BDNF promotes the regenerative sprouting, but not survival, of injured serotonergic axons in the adult rat brain, J Neurosci, vol.20, pp.771-782, 2000.

N. Salichon, P. Gaspar, A. Upton, S. Picaud, N. Hanoun et al., Excessive activation of serotonin (5-HT) 1B receptors disrupts the formation of sensory maps in monoamine oxidase a and 5-ht transporter knock-out mice, J Neurosci, vol.21, pp.884-96, 2001.

C. Bradley and R. Blakely, Alternative Splicing of the Human Serotonin Transporter Gene, Journal of Neurochemistry, vol.69, issue.4, pp.1356-1367, 1997.
DOI : 10.1046/j.1471-4159.1997.69041356.x

A. Heinz, D. Braus, M. Smolka, J. Wrase, I. Puls et al., Amygdala-prefrontal coupling depends on a genetic variation of the serotonin transporter, Nature Neuroscience, vol.985, issue.1, pp.20-21, 2005.
DOI : 10.1016/j.neuroimage.2003.09.057

L. Pezawas, A. Meyer-lindenberg, E. Drabant, B. Verchinski, K. Munoz et al., 5-HTTLPR polymorphism impacts human cingulate-amygdala interactions: a genetic susceptibility mechanism for depression, Nature Neuroscience, vol.43, issue.6, pp.828-834, 2005.
DOI : 10.1073/pnas.111134598

C. Watson, F. Hoeft, A. Garrett, S. Hall, and A. Reiss, Aberrant Brain Activation During Gaze Processing in Boys With Fragile X Syndrome, Archives of General Psychiatry, vol.65, issue.11, pp.1315-1323, 2008.
DOI : 10.1001/archpsyc.65.11.1315

A. Meyer-lindenberg, A. Hariri, K. Munoz, C. Mervis, V. Mattay et al., Neural correlates of genetically abnormal social cognition in Williams syndrome, Nature Neuroscience, vol.23, issue.8, pp.991-993, 2005.
DOI : 10.1016/j.pneurobio.2004.03.006

K. Lesch, D. Bengel, A. Heils, S. Sabol, B. Greenberg et al., Association of Anxiety-Related Traits with a Polymorphism in the Serotonin Transporter Gene Regulatory Region, Science, vol.274, issue.5292, pp.1527-1531, 1996.
DOI : 10.1126/science.274.5292.1527

X. Hu, G. Oroszi, J. Chun, T. Smith, D. Goldman et al., An Expanded Evaluation of the Relationship of Four Alleles to the Level of Response to Alcohol and the Alcoholism Risk, Alcoholism: Clinical & Experimental Research, vol.22, issue.1, pp.8-16, 2005.
DOI : 10.1111/j.1530-0277.2003.tb02715.x

A. Fallgatter, A. Bartsch, and M. Herrmann, Electrophysiological measurements of anterior cingulate function, Journal of Neural Transmission, vol.109, issue.5-6, pp.977-988, 2002.
DOI : 10.1007/s007020200080

T. Canli and K. Lesch, Long story short: the serotonin transporter in emotion regulation and social cognition, Nature Neuroscience, vol.90, issue.9, pp.1103-1109, 2007.
DOI : 10.1038/nn1964

A. Mackenzie and J. Quinn, serotonin transporter gene intron 2 polymorphic region, correlated with affective disorders, has allele-dependent Tabagh et al. BMC Medical Genetics differential enhancer-like properties in the mouse embryo, Proc Natl Acad Sci, vol.111130, issue.96, pp.3015251-15255, 1999.

S. Battersby, A. Ogilvie, D. Blackwood, S. Shen, M. Muqit et al., Presence of Multiple Functional Polyadenylation Signals and a Single Nucleotide Polymorphism in the 3??? Untranslated Region of the Human Serotonin Transporter Gene, Journal of Neurochemistry, vol.15, issue.4, pp.1384-1388, 1999.
DOI : 10.1046/j.1471-4159.1999.721384.x

R. Ren-patterson, L. Cochran, A. Holmes, S. Sherrill, S. Huang et al., Loss of brain-derived neurotrophic factor gene allele exacerbates brain monoamine deficiencies and increases stress abnormalities of serotonin transporter knockout mice, Journal of Neuroscience Research, vol.877, issue.6, pp.756-771, 2005.
DOI : 10.1002/jnr.20410

L. Daws, J. Munn, M. Valdez, T. Frosto-burke, and J. Hensler, Serotonin transporter function, but not expression, is dependent on brain-derived neurotrophic factor (BDNF): in vivo studies in BDNF-deficient mice, Journal of Neurochemistry, vol.65, issue.3, pp.641-651, 2007.
DOI : 10.1111/j.1471-4159.2006.04392.x

J. Siuciak, C. Boylan, M. Fritsche, C. Altar, and R. Lindsay, BDNF increases monoaminergic activity in rat brain following intracerebroventricular or intraparenchymal administration, Brain Research, vol.710, issue.1-2, pp.11-20, 1996.
DOI : 10.1016/0006-8993(95)01289-3

M. Yamada, K. Nakanishi, S. Ohba, T. Nakamura, Y. Ikegaya et al., Brain-derived neurotrophic factor promotes the maturation of GABAergic mechanisms in cultured hippocampal neurons, J Neurosci, vol.22, pp.7580-7585, 2002.

Q. Liu, D. Walther, T. Drgon, O. Polesskaya, T. Lesnick et al., Human brain derived neurotrophic factor (BDNF) genes, splicing patterns, and assessments of associations with substance abuse and Parkinson's Disease, American Journal of Medical Genetics Part B: Neuropsychiatric Genetics, vol.88, issue.1, pp.93-103, 2005.
DOI : 10.1002/ajmg.b.30109

M. Egan, M. Kojima, J. Callicott, T. Goldberg, B. Kolachana et al., The BDNF val66met Polymorphism Affects Activity-Dependent Secretion of BDNF and Human Memory and Hippocampal Function, Cell, vol.112, issue.2, pp.257-269, 2003.
DOI : 10.1016/S0092-8674(03)00035-7

F. Miyajima, W. Ollier, A. Mayes, A. Jackson, N. Thacker et al., Brain-derived neurotrophic factor polymorphism Val66Met influences cognitive abilities in the elderly, Genes, Brain and Behavior, vol.16, issue.4, pp.411-417, 2008.
DOI : 10.1111/j.1601-183X.2007.00363.x

V. Singh, E. Singh, and R. Warren, Hyperserotoninemia and serotonin receptor antibodies in children with autism but not mental retardation, Biological Psychiatry, vol.41, issue.6, pp.753-755, 1997.
DOI : 10.1016/S0006-3223(96)00522-7

K. Nelson, J. Grether, L. Croen, J. Dambrosia, B. Dickens et al., Neuropeptides and neurotrophins in neonatal blood of children with autism or mental retardation, Annals of Neurology, vol.122, issue.5, pp.597-606, 2001.
DOI : 10.1002/ana.1024

K. Miyazaki, N. Narita, R. Sakuta, T. Miyahara, H. Naruse et al., Serum neurotrophin concentrations in autism and mental retardation: a pilot study, Brain and Development, vol.26, issue.5, pp.292-295, 2004.
DOI : 10.1016/S0387-7604(03)00168-2

J. Wendland, B. Martin, M. Kruse, K. Lesch, and D. Murphy, Simultaneous genotyping of four functional loci of human SLC6A4, with a reappraisal of 5-HTTLPR and rs25531, Molecular Psychiatry, vol.29, issue.3, pp.224-226, 2006.
DOI : 10.1038/sj.mp.4001789

E. Cook, . Jr, R. Courchesne, C. Lord, N. Cox et al., Evidence of linkage between the serotonin transporter and autistic disorder, Mol Psychiatry, vol.2, pp.247-250, 1997.

J. Bland and D. Altman, Statistics Notes: The odds ratio, BMJ, vol.320, issue.7247, p.1468, 2000.
DOI : 10.1136/bmj.320.7247.1468

K. Martinowich and B. Lu, Interaction between BDNF and Serotonin: Role in Mood Disorders, Neuropsychopharmacology, vol.17, issue.1, pp.73-83, 2008.
DOI : 10.1016/S0165-3806(99)00152-2

A. Heils, A. Teufel, S. Petri, G. Stöber, P. Riederer et al., Allelic Variation of Human Serotonin Transporter Gene Expression, Journal of Neurochemistry, vol.66, issue.6, pp.2621-2624, 1996.
DOI : 10.1046/j.1471-4159.1996.66062621.x

D. Collier, G. Stöber, T. Li, A. Heils, M. Catalano et al., A novel functional polymorphism within the promoter of the serotonin transporter gene: possible role in susceptibility to affective disorders, Mol Psychiatry, vol.1, pp.453-460, 1996.

D. Eckert, S. Buhl, S. Weber, R. Jager, and H. Schorle, The AP-2 family of transcription factors, Genome Biology, vol.6, issue.13, p.246, 2005.
DOI : 10.1186/gb-2005-6-13-246

X. Hu, R. Lipsky, G. Zhu, L. Akhtar, J. Taubman et al., Serotonin Transporter Promoter Gain-of-Function Genotypes Are Linked to Obsessive-Compulsive Disorder, The American Journal of Human Genetics, vol.78, issue.5, pp.815-826, 2006.
DOI : 10.1086/503850

S. Harris, H. Fox, A. Wright, C. Hayward, J. Starr et al., The brain-derived neurotrophic factor Val66Met polymorphism is associated with age-related change in reasoning skills, Molecular Psychiatry, vol.7, issue.5, pp.505-513, 2006.
DOI : 10.1038/sj.mp.4001799

P. Pruunsild, A. Kazantseva, T. Aid, K. Palm, and T. Timmusk, Dissecting the human BDNF locus: Bidirectional transcription, complex splicing, and multiple promoters, Genomics, vol.90, issue.3, pp.397-406, 2007.
DOI : 10.1016/j.ygeno.2007.05.004

J. Kaufman, B. Yang, H. Douglas-palumberi, D. Grasso, D. Lipschitz et al., Brain-Derived Neurotrophic Factor???5-HTTLPR Gene Interactions and Environmental Modifiers of Depression in Children, Biological Psychiatry, vol.59, issue.8, pp.673-680, 2006.
DOI : 10.1016/j.biopsych.2005.10.026

R. Hünnerkopf, A. Strobel, L. Gutknecht, B. Brocke, and K. Lesch, Interaction between BDNF Val66Met and Dopamine Transporter Gene Variation Influences Anxiety-Related Traits, Neuropsychopharmacology, vol.252, issue.12, pp.2552-2560, 2007.
DOI : 10.1038/sj.npp.1301383

T. Frodl, C. Schüle, G. Schmitt, C. Born, T. Baghai et al., Association of the Brain-Derived Neurotrophic Factor Val66Met Polymorphism With Reduced Hippocampal Volumes in Major Depression, Archives of General Psychiatry, vol.64, issue.4, pp.410-416, 2007.
DOI : 10.1001/archpsyc.64.4.410

R. Philibert, A. Madan, A. Andersen, R. Cadoret, H. Packer et al., Serotonin transporter MDNA levels are associated with the methylation of an upstream CpG island, Am J Med Genet B Neuropsychiatr Genet, vol.144, pp.101-105, 2007.

T. Bredy, H. Wu, C. Crego, J. Zellhoefer, Y. Sun et al., Histone modifications around individual BDNF gene promoters in prefrontal cortex are associated with extinction of conditioned fear, Learning & Memory, vol.14, issue.4, pp.268-276, 2007.
DOI : 10.1101/lm.500907