Abstract : Lost of adenomatous polyposis coli gene (Apc) disturbs the migration of intestinal epithelial cells but the mechanisms have not been fully characterized. Since we have demonstrated that SK3/KCa2.3 channel promotes cancer cell migration, we hypothesized that Apc mutation may affect SK3/KCa2.3 channel-mediated colon epithelial cell motility. We report evidence that SK3/KCa2.3 channel promotes colon epithelial cells motility. Following Apc mutation SK3/KCa2.3 expression is largely reduced leading to a suppression of the SK3/KCa2.3 channel mediated-cell migration. Our findings reveal a previously unknown function of the SK3/KCa2.3 channel in epithelial colonic cells, and suggest that Apc is a powerful regulator SK3/KCa2.3 channel.
Type de document :
Article dans une revue
Biochemical and Biophysical Research Communications, Elsevier, 2010, 397 (1), pp.42-7. 〈10.1016/j.bbrc.2010.05.046〉
http://www.hal.inserm.fr/inserm-00662363
Contributeur : Christophe Vandier
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Soumis le : lundi 23 janvier 2012 - 21:29:09
Dernière modification le : samedi 15 septembre 2018 - 01:09:39
