Altered SK3/KCa2.3-mediated migration in adenomatous polyposis coli (Apc) mutated mouse colon epithelial cells. - Archive ouverte HAL Access content directly
Journal Articles Biochemical and Biophysical Research Communications Year : 2010

Altered SK3/KCa2.3-mediated migration in adenomatous polyposis coli (Apc) mutated mouse colon epithelial cells.

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Abstract

Lost of adenomatous polyposis coli gene (Apc) disturbs the migration of intestinal epithelial cells but the mechanisms have not been fully characterized. Since we have demonstrated that SK3/KCa2.3 channel promotes cancer cell migration, we hypothesized that Apc mutation may affect SK3/KCa2.3 channel-mediated colon epithelial cell motility. We report evidence that SK3/KCa2.3 channel promotes colon epithelial cells motility. Following Apc mutation SK3/KCa2.3 expression is largely reduced leading to a suppression of the SK3/KCa2.3 channel mediated-cell migration. Our findings reveal a previously unknown function of the SK3/KCa2.3 channel in epithelial colonic cells, and suggest that Apc is a powerful regulator SK3/KCa2.3 channel.
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Dates and versions

inserm-00662363 , version 1 (23-01-2012)

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Marie Potier-Cartereau, Truong-An Tran, Aurélie Chantôme, Alban Girault, Virginie Joulin, et al.. Altered SK3/KCa2.3-mediated migration in adenomatous polyposis coli (Apc) mutated mouse colon epithelial cells.. Biochemical and Biophysical Research Communications, 2010, 397 (1), pp.42-7. ⟨10.1016/j.bbrc.2010.05.046⟩. ⟨inserm-00662363⟩
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