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Journal articles
Altered SK3/KCa2.3-mediated migration in adenomatous polyposis coli (Apc) mutated mouse colon epithelial cells.
Abstract : Lost of adenomatous polyposis coli gene (Apc) disturbs the migration of intestinal epithelial cells but the mechanisms have not been fully characterized. Since we have demonstrated that SK3/KCa2.3 channel promotes cancer cell migration, we hypothesized that Apc mutation may affect SK3/KCa2.3 channel-mediated colon epithelial cell motility. We report evidence that SK3/KCa2.3 channel promotes colon epithelial cells motility. Following Apc mutation SK3/KCa2.3 expression is largely reduced leading to a suppression of the SK3/KCa2.3 channel mediated-cell migration. Our findings reveal a previously unknown function of the SK3/KCa2.3 channel in epithelial colonic cells, and suggest that Apc is a powerful regulator SK3/KCa2.3 channel.
https://www.hal.inserm.fr/inserm-00662363
Contributor : Christophe Vandier Connect in order to contact the contributor
Submitted on : Monday, January 23, 2012 - 9:29:09 PM
Last modification on : Friday, January 14, 2022 - 5:24:01 PM
Contributor : Christophe Vandier Connect in order to contact the contributor
Submitted on : Monday, January 23, 2012 - 9:29:09 PM
Last modification on : Friday, January 14, 2022 - 5:24:01 PM