Skip to Main content Skip to Navigation
Journal articles

HbA1c, fasting plasma glucose and the prediction of diabetes: Inter99, AusDiab and D.E.S.I.R.: HbA1c, FPG and prediction of diabetes

Abstract : INTRODUCTION: With diabetes defined by HbA1c≥6.5% and/or FPG≥7.0mmol/l and/or diabetes treatment, we investigated HbA1c and fasting plasma glucose (FPG) thresholds/change-points above which the incidence of diabetes increases. METHODS: Data are Danish (Inter99), Australian (AusDiab) and French (D.E.S.I.R.), with respectively 4930, 6012 and 3784 non-diabetic participants. RESULTS: Diabetes incidences at 5 years for Inter99 and AusDiab and at 6 years for D.E.S.I.R. were 2.3%, 3.1% and 2.4% respectively and incidences increased with baseline HbA1c and FPG. As HbA1c distributions differed between cohorts, HbA1c was standardized on D.E.S.I.R. data. Change-points where diabetes incidence increased were identified for HbA1c (%) after standardization: 5.1 (4.9-5.6) (Inter99), 5.4 (5.1-5.6) (AusDiab), 5.3 (5.1-5.7) (D.E.S.I.R.); for FPG change-points (mmol/l) were 5.1 (...-6.1) (Inter99), 5.5 (5.2-5.8) (AusDiab), no change-point for D.E.S.I.R. Using current diabetes risk criteria HbA1c≥5.7% and/or FPG≥5.6mmol/l to screen for diabetes provided high sensitivity (over 89%) and positive predictive values: 4.3%, 6.9%, and 5.9% respectively. CONCLUSIONS: HbA1c and FPG change-points predicting incident diabetes did not always exist, differed across studies, when available were generally lower than current criteria with wide confidence intervals. Using jointly HbA1c≥5.7% and/or FPG≥5.6mmol/l as a criterion for the risk of incident diabetes is appropriate.
Document type :
Journal articles
Complete list of metadatas

Cited literature [31 references]  Display  Hide  Download

https://www.hal.inserm.fr/inserm-00659373
Contributor : Blandine de Lauzon-Guillain <>
Submitted on : Thursday, January 12, 2012 - 4:15:09 PM
Last modification on : Wednesday, October 14, 2020 - 4:04:51 AM
Long-term archiving on: : Friday, April 13, 2012 - 2:31:13 AM

Files

Soulimane_DRCP_HAL_13_07_2011....
Files produced by the author(s)

Identifiers

Collections

Citation

Soraya Soulimane, Dominique Simon, Jonathan Shaw, Daniel Witte, Paul Zimmet, et al.. HbA1c, fasting plasma glucose and the prediction of diabetes: Inter99, AusDiab and D.E.S.I.R.: HbA1c, FPG and prediction of diabetes. Diabetes Research and Clinical Practice, Elsevier, 2012, 96 (3), pp.392-9. ⟨10.1016/j.diabres.2011.06.003⟩. ⟨inserm-00659373⟩

Share

Metrics

Record views

535

Files downloads

1164