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[The role of co-inhibitory signals driven by CTLA-4 in immune system].

Abstract : Key players on the immunosurveillance program, T cells are regulated by their surface receptors such as T-cell receptor (TCR), and costimulatory molecules, optimizing T-cell activation. Some of these costimulatory molecules, such as the cytotoxic T-lymphocyte antigen 4 (CTLA-4), induce inhibitory effects on T cells. By "inhibiting the inhibitor" CTLA-4-blocking monoclonal antibodies represent a novel class of weapons against cancers. To better understand the promising future and the limits of this immunotherapy, this review dissects the molecular inhibitory mechanisms induced by CTLA-4 in T cells.
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Contributor : Jacques Nunès Connect in order to contact the contributor
Submitted on : Sunday, October 21, 2012 - 7:00:03 AM
Last modification on : Monday, February 14, 2022 - 10:20:12 AM
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Daniel Olive, Suong Le Thi, Luc Xerri, Ivan Hirsch, Jacques A. Nunès. [The role of co-inhibitory signals driven by CTLA-4 in immune system].. médecine/sciences, EDP Sciences, 2011, 27 (10), pp.842-9. ⟨10.1051/medsci/20112710012⟩. ⟨inserm-00659319⟩



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