Vasopressin, ATP and catecholamines differentially control potassium secretion in inner ear cell line.

Jérôme Nevoux; Marie Teixeira; Say Viengchareun; Claudine Cosson; Daniel Butlen; Marc Lombes; Evelyne Ferrary

doi:10.1016/j.febslet.2011.07.025

Vasopressin, ATP and catecholamines differentially control potassium secretion in inner ear cell line.

Jérôme Nevoux ^{1, 2} Marie Teixeira ² Say Viengchareun ¹ Claudine Cosson ³ Daniel Butlen ² Marc Lombes ^{1, 4} Evelyne Ferrary ^{2, 5, *}

* Auteur correspondant

1 Récepteurs stéroïdiens : physiopathologie endocrinienne et métabolique

2 Chirurgie otologique mini-invasive robotisée

3 Service de Biochimie [Bicêtre]

4 Service d'Endocrinologie et Maladies de la reproduction

5 Service d'ORL

Abstract : A strict control of endolymph composition (high potassium, low sodium fluid) and volume is instrumental for a proper functioning of the inner ear. Alteration of endolymph homeostasis is proposed in the pathogenesis of Menière's disease. However, the mechanisms controlling endolymph secretion remain elusive. By using the vestibular EC5v cells, we provide evidence for the presence of vasopressin, catecholamine and purinergic signaling pathways, coupled to adenylate cyclase, phosphoinositidase C and Ca(2+) activation. We demonstrate that vasopressin and catecholamines stimulate while ATP inhibits apical potassium secretion by EC5v cells. These results open new interesting perspectives for the management of inner ear diseases.

Keywords : endolymph vasopressin receptors Menière's disease vestibular cells purinergic receptors

Type de document :

Article dans une revue

FEBS Letters, Wiley, 2011, 585 (17), pp.2703-8. 〈10.1016/j.febslet.2011.07.025〉

Domaine :

Sciences du Vivant [q-bio] / Médecine humaine et pathologie / Organes des sens

Liste complète des métadonnées

http://www.hal.inserm.fr/inserm-00656238
Contributeur : Marc Lombes <>
Soumis le : jeudi 13 septembre 2012 - 11:50:22
Dernière modification le : mercredi 25 juillet 2018 - 10:52:02

Vasopressin, ATP and catecholamines differentially control potassium secretion in inner ear cell line.

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Vasopressin, ATP and catecholamines differentially control potassium secretion in inner ear cell line.

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