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Vasopressin, ATP and catecholamines differentially control potassium secretion in inner ear cell line.

Abstract : A strict control of endolymph composition (high potassium, low sodium fluid) and volume is instrumental for a proper functioning of the inner ear. Alteration of endolymph homeostasis is proposed in the pathogenesis of Menière's disease. However, the mechanisms controlling endolymph secretion remain elusive. By using the vestibular EC5v cells, we provide evidence for the presence of vasopressin, catecholamine and purinergic signaling pathways, coupled to adenylate cyclase, phosphoinositidase C and Ca(2+) activation. We demonstrate that vasopressin and catecholamines stimulate while ATP inhibits apical potassium secretion by EC5v cells. These results open new interesting perspectives for the management of inner ear diseases.
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https://www.hal.inserm.fr/inserm-00656238
Contributor : Marc Lombes <>
Submitted on : Thursday, September 13, 2012 - 11:50:22 AM
Last modification on : Wednesday, September 16, 2020 - 5:06:36 PM

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Jérôme Nevoux, Marie Teixeira, Say Viengchareun, Claudine Cosson, Daniel Butlen, et al.. Vasopressin, ATP and catecholamines differentially control potassium secretion in inner ear cell line.. FEBS Letters, Wiley, 2011, 585 (17), pp.2703-8. ⟨10.1016/j.febslet.2011.07.025⟩. ⟨inserm-00656238⟩

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