Skip to Main content Skip to Navigation
Journal articles

Cell-derived microparticles in atherosclerosis: biomarkers and targets for pharmacological modulation?

Abstract : Cardiovascular diseases remain an important cause of morbi-mortality. Atherosclerosis, which predisposes to cardiovascular disorders such as myocardial infarction and stroke, develops silently over several decades. Identification of circulating biomarkers to evaluate cardiovascular event risk and pathology prognosis is of particular importance. Microparticles (MPs) are small vesicles released from cells upon apoptosis or activation. Microparticles are present in blood of healthy individuals. Studies showing a modification of their concentrations in patients with cardiovascular risk factors and after cardiovascular events identify MPs as potential biomarkers of disease. Moreover, the pathophysiological properties of MPs may contribute to atherosclerosis development. In addition, pharmacological compounds, used in the treatment of cardiovascular disease, can reduce plasma MP concentrations. Nevertheless, numerous issues remain to be solved before MP measurement can be applied as routine biological tests to improve cardiovascular risk prediction. In particular, prospective studies to identify the predictive values of MPs in pathologies such as cardiovascular diseases are needed to demonstrate whether MPs are useful biomarkers for the early detection of the disease and its progression.
Document type :
Journal articles
Complete list of metadatas

Cited literature [49 references]  Display  Hide  Download

https://www.hal.inserm.fr/inserm-00656089
Contributor : Marie-Hélène Derudas <>
Submitted on : Tuesday, January 3, 2012 - 3:29:33 PM
Last modification on : Sunday, October 25, 2020 - 7:07:57 AM
Long-term archiving on: : Monday, November 19, 2012 - 12:10:29 PM

File

jcmm1486.pdf
Publisher files allowed on an open archive

Identifiers

Citation

Morgane Baron, Chantal Boulanger, Bart Staels, Anne Tailleux. Cell-derived microparticles in atherosclerosis: biomarkers and targets for pharmacological modulation?. Journal of Cellular and Molecular Medicine, Wiley Open Access, 2012, 16 (7), pp.1365-76. ⟨10.1111/j.1582-4934.2011.01486.x⟩. ⟨inserm-00656089⟩

Share

Metrics

Record views

532

Files downloads

1059