O. V. Aslanidi, M. A. Colman, J. Stott, and H. Dobrzynski, 3D virtual human atria: A computational platform for studying clinical atrial fibrillation, Progress in Biophysics and Molecular Biology, vol.107, issue.1, pp.pp-pp, 2011.
DOI : 10.1016/j.pbiomolbio.2011.06.011

S. A. Atlas, The Renin-Angiotensin Aldosterone System: Pathophysiological Role and Pharmacologic Inhibition, Journal of Managed Care Pharmacy, vol.13, issue.8 Supp B, pp.9-20, 2007.
DOI : 10.18553/jmcp.2007.13.s8-b.9

P. Auger, D. Parra, and B. , Methods of aggregation of variables in population dynamics, Comptes rendus de l'Académie des sciences, Sciences de la vie, pp.665-674, 2000.

P. Auger and C. Lett, Integrative biology: linking levels of organization, Comptes Rendus Biologies, vol.326, issue.5, pp.517-522, 2003.
DOI : 10.1016/S1631-0691(03)00115-X

M. J. Brown, Renin: friend or foe?, Heart, pp.1026-1059, 2007.
DOI : 10.1136/hrt.2006.107706

URL : http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1955008

R. H. Clayton, O. Bernus, E. M. Cherry, H. Dierckx, F. H. Fenton et al., Models of cardiac tissue electrophysiology: Progress, challenges and open questions, Progress in Biophysics and Molecular Biology, pp.22-48, 2011.
DOI : 10.1016/j.pbiomolbio.2010.05.008

R. H. Clayton and A. V. Panfilov, A guide to modelling cardiac electrical activity in anatomically detailed ventricles, Progress in Biophysics and Molecular Biology, vol.96, issue.1-3, pp.19-43, 2008.
DOI : 10.1016/j.pbiomolbio.2007.07.004

J. Fleureau, M. Garreau, E. Donal, C. Leclercq, and A. I. Hernández, A Hybrid Tissue-Level Model of the Left Ventricle: Application to the Analysis of the Regional Cardiac Function in Heart Failure, Functional Imaging and Modeling of the Heart, pp.258-267, 2009.
DOI : 10.1016/j.media.2006.04.001

URL : https://hal.archives-ouvertes.fr/inserm-00392548

F. Guillaud and P. Hannaert, A Computational Model of the Circulating Renin-Angiotensin System and Blood Pressure Regulation, Acta Biotheoretica, vol.296, issue.1, pp.143-70, 2010.
DOI : 10.1007/s10441-010-9098-5

A. C. Guyton, Circulatory Physiology I. Cardiac Output and Its Regulation, 1973.

A. C. Guyton, Circulatory Physiology II. Dynamics and Control of Body Fluid, 1975.

A. C. Guyton, Circulatory Physiology III. Arterial Pressure and Hypertension, 1980.

A. C. Guyton, T. G. Coleman, and H. J. Granger, Circulation: Overall Regulation, Annual Review of Physiology, vol.34, issue.1, pp.13-46, 1972.
DOI : 10.1146/annurev.ph.34.030172.000305

A. Hernández, V. Le-rolle, A. Defontaine, and G. Carrault, A multiformalism and multiresolution modelling environment: application to the cardiovascular system and its regulation, Philosophical Transactions of the Royal Society A: Mathematical, Physical and Engineering Sciences, vol.22, issue.5, pp.4923-4940, 2009.
DOI : 10.1529/biophysj.103.035840

R. L. Hester, R. Iliescu, R. Summers, and T. G. Coleman, Systems biology and integrative physiological modelling, The Journal of Physiology, pp.1053-1060, 2011.

D. Houle, D. R. Govindaraju, and S. Omholt, Phenomics: the next challenge, Nature Reviews Genetics, vol.11, issue.113, pp.855-866, 2010.
DOI : 10.1038/nrg2897

B. S. Hsieh, Y. M. Chen, K. D. Wu, Y. M. Kuo, C. H. Hsieh et al., A simulation study on renin and aldosterone secretions in primary aldosteronism, J Formos Med Assoc, vol.89, pp.346-355, 1990.

W. A. Hsueh and K. Wyne, Renin-Angiotensin-Aldosterone System in Diabetes and Hypertension, The Journal of Clinical Hypertension, vol.112, issue.17, pp.224-261, 2011.
DOI : 10.1111/j.1751-7176.2011.00449.x

P. Hunter, P. V. Coveney, B. De-bono, V. Diaz, J. Fenner et al., A vision and strategy for the virtual physiological human in 2010 and beyond, Philosophical Transactions of the Royal Society A: Mathematical, Physical and Engineering Sciences, vol.366, issue.1920, p.2595, 2010.
DOI : 10.1098/rsta.2010.0048

N. Ikeda, F. Marumo, M. Shirataka, and T. Sato, A model of overall regulation of body fluids, Annals of Biomedical Engineering, vol.234, issue.2, pp.135-166, 1979.
DOI : 10.1007/BF02363132

X. Jiang, H. Sheng, J. Li, P. Xun, Y. Cheng et al., Association between renin???angiotensin system gene polymorphism and essential hypertension: a community-based study, Journal of Human Hypertension, vol.29, issue.3, pp.176-81, 2009.
DOI : 10.1038/jhh.2008.123

H. Joshi, A. B. Singharoy, Y. V. Sereda, S. Cheluvaraja, and P. J. Ortoleva, Multiscale simulation of microbe structure and dynamics, Progress in Biophysics and Molecular Biology, vol.107, issue.1, pp.pp-pp, 2011.
DOI : 10.1016/j.pbiomolbio.2011.07.006

F. Karaaslan, Y. Denizhan, A. Kayserilioglu, and H. O. Gulcur, Long-Term Mathematical Model Involving Renal Sympathetic Nerve Activity, Arterial Pressure, and Sodium Excretion, Annals of Biomedical Engineering, vol.23, issue.1, pp.1607-1637, 2005.
DOI : 10.1007/s10439-005-5976-4

URL : http://citeseerx.ist.psu.edu/viewdoc/summary?doi=

R. C. Kerckhoffs, S. N. Healy, T. P. Usyk, and A. D. Mcculloch, Computational Methods for Cardiac Electromechanics, Proceedings of the IEEE, pp.769-783, 2006.
DOI : 10.1109/JPROC.2006.871772

J. Kofranek and J. Rusz, Restoration of Guyton s diagram for regulation of the circulation as a basis for quantitative physiological model development, Physiol Res, vol.59, pp.897-908, 2010.

J. Kofranek, J. Rusz, and S. Matouöek, Guytons Diagram Brought to Life-from Graphic Chart to Simulation Model for Teaching Physiology, Technical Computing Prague, pp.978-80, 2007.

J. Laragh, Laragh's lessons in pathophysiology and clinical pearls for treating hypertension, American Journal of Hypertension, vol.14, issue.2, pp.186-94, 2001.
DOI : 10.1016/S0895-7061(00)01317-0

J. H. Laragh, Renin-angiotensin-aldosterone system for blood pressure and electrolyte homeostasis and its involvement in hypertension, in congestive heart failure and in associated cardiovascular damage (myocardial infarction and stroke), J Hum Hypertens, vol.9, pp.385-90, 1995.

L. Rolle, V. Hernández, A. I. Richard, P. Donal, E. Carrault et al., Model-based analysis of myocardial strain data acquired by tissue Doppler imaging, Artificial Intelligence in Medicine, vol.44, issue.3, pp.201-219, 2008.
DOI : 10.1016/j.artmed.2008.06.001

URL : https://hal.archives-ouvertes.fr/inserm-00336116

H. Lischke, T. J. Loffler, P. E. Thornton, and N. E. Zimmermann, Model up-scaling in landscape research, A Changing World, pp.249-272, 2007.

S. Malpas, Osborn exchange of views, Experimental Physiology, vol.94, issue.4, pp.381-382, 2009.
DOI : 10.1113/expphysiol.2008.043273

H. Martens, S. R. Veflingstad, E. Plahte, M. Martens, D. Bertrand et al., The genotypephenotype relationship in multicellular pattern-generating models-the neglected role of pattern descriptors, BMC Systems Biology, vol.3, issue.87, 2009.

J. J. Mcmurray, Systolic Heart Failure, New England Journal of Medicine, vol.362, issue.3, pp.228-238, 2010.
DOI : 10.1056/NEJMcp0909392

J. P. Montani, V. Vliet, and B. N. , Understanding the contribution of Guyton's large circulatory model to long-term control of arterial pressure, Experimental Physiology, vol.113, issue.1, pp.382-390, 2009.
DOI : 10.1113/expphysiol.2008.043299

M. Morris, Factorial Sampling Plans for Preliminary Computational Experiments, Technometrics, vol.1, issue.2, pp.161-174, 1991.
DOI : 10.2307/1266468

D. A. Nordsletten, S. A. Niederer, M. P. Nash, P. J. Hunter, and N. P. Smith, Coupling multi-physics models to cardiac mechanics, Progress in Biophysics and Molecular Biology, vol.104, issue.1-3, pp.77-88, 2011.
DOI : 10.1016/j.pbiomolbio.2009.11.001

M. Paul, P. Mehr, A. Kreutz, and R. , Physiology of Local Renin-Angiotensin Systems, Physiological Reviews, vol.86, issue.3, pp.747-803, 2006.
DOI : 10.1152/physrev.00036.2005

O. Rompelman, A. J. Coenen, and R. Kitney, Measurement of heart-rate variability: Part 1, 1977.

M. Rudnicki and G. Mayer, Significance of genetic polymorphisms of the renin???angiotensin???aldosterone system in cardiovascular and renal disease, Pharmacogenomics, vol.10, issue.3, pp.463-76, 2009.
DOI : 10.2217/14622416.10.3.463

B. W. Smith, J. G. Chase, R. I. Nokes, G. M. Shaw, and G. Wake, Minimal haemodynamic system model including ventricular interaction and valve dynamics, Minimal haemodynamic system model including ventricular interaction and valve dynamics, pp.131-139, 2004.
DOI : 10.1016/j.medengphy.2003.10.001

C. M. Smith-spangler, J. L. Juusola, E. A. Enns, D. K. Owens, and A. M. Garber, Population Strategies to Decrease Sodium Intake and the Burden of Cardiovascular Disease, Annals of Internal Medicine, vol.152, issue.8, pp.481-488, 2010.
DOI : 10.7326/0003-4819-152-8-201004200-00212

N. Takahashi, J. R. Hagaman, H. S. Kim, and O. Smithies, Minireview: Computer Simulations of Blood Pressure Regulation by the Renin-Angiotensin System, Endocrinology, vol.144, issue.6, pp.2184-90, 2003.
DOI : 10.1210/en.2002-221045

S. R. Thomas, P. Baconnier, J. Fontecave, J. P. Francoise, F. Guillaud et al., SAPHIR: a physiome core model of body fluid homeostasis and blood pressure regulation, Philosophical Transactions of the Royal Society A: Mathematical, Physical and Engineering Sciences, vol.31, issue.1, pp.3175-97, 2008.
DOI : 10.1016/S0273-1177(02)00652-X

URL : https://hal.archives-ouvertes.fr/hal-00339613

K. Tse-ve-koon, C. Thebault, V. Le-rolle, and A. I. Hernández, Atrioventricular Delay Optimization in Cardiac Resynchronization Therapy assesed by a computer model In : Computing in Cardiology, pp.333-336, 2010.

R. J. Uttamsingh, M. S. Leaning, J. A. Bushman, E. R. Carson, and L. Finkelstein, Mathematical model of the human renal system, Mathematical model of the human renal system, pp.525-560, 1985.
DOI : 10.1007/BF02455306

V. Vliet, B. N. Montani, and J. P. , Circulation and fluid volume control, Integrative physiology in the proteomics and post-genomics age, p.43, 2005.