Integration of detailed modules in a core model of body fluid homeostasis and blood pressure regulation.

Alfredo Hernández 1, * Virginie Le Rolle 2 David Ojeda 2 Pierre Baconnier 3 Julie Fontecave-Jallon 3 François Guillaud 4 Thibault Grosse 5 Robert Moss 5 Patrick Hannaert 4 Randall Thomas 5
* Auteur correspondant
1 LTSI - Laboratoire Traitement du Signal et de l'Image
2 LTSI - Laboratoire Traitement du Signal et de l'Image
3 PRETA
TIMC-IMAG - Techniques de l'Ingénierie Médicale et de la Complexité - Informatique, Mathématiques et Applications [Grenoble]
4 Ischémie - Reperfusion en transplatation rénale
5 IR4M - Imagerie par Résonance Magnétique Médicale et Multi-Modalités
Abstract : This paper presents a contribution to the definition of the interfaces required to perform heterogeneous model integration in the context of integrative physiology. A formalization of the model integration problem is proposed and a coupling method is presented. The extension of the classic Guyton model, a multi-organ, integrated systems model of blood pressure regulation, is used as an example of the application of the proposed method. To this end, the Guyton model has been restructured, extensive sensitivity analyses have been performed, and appropriate transformations have been applied to replace a subset of its constituting modules by integrating a pulsatile heart and an updated representation of the renin-angiotensin system. Simulation results of the extended integrated model are presented and the impacts of their integration within the original model are evaluated.
Keywords : Model interactions Heterogeneous model coupling Cardiovascular physiology Cardiac function Renin-angiotensin system
Type de document :
Article dans une revue
Progress in Biophysics and Molecular Biology, Elsevier, 2011, 107 (1), pp.169-82. 〈10.1016/j.pbiomolbio.2011.06.008〉
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Alfredo Hernández, Virginie Le Rolle, David Ojeda, Pierre Baconnier, Julie Fontecave-Jallon, et al.. Integration of detailed modules in a core model of body fluid homeostasis and blood pressure regulation.. Progress in Biophysics and Molecular Biology, Elsevier, 2011, 107 (1), pp.169-82. 〈10.1016/j.pbiomolbio.2011.06.008〉. 〈inserm-00654821〉

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