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Resveratrol improves survival, hemodynamics and energetics in a rat model of hypertension leading to heart failure.

Abstract : Heart failure (HF) is characterized by contractile dysfunction associated with altered energy metabolism. This study was aimed at determining whether resveratrol, a polyphenol known to activate energy metabolism, could be beneficial as a metabolic therapy of HF. Survival, ventricular and vascular function as well as cardiac and skeletal muscle energy metabolism were assessed in a hypertensive model of HF, the Dahl salt-sensitive rat fed with a high-salt diet (HS-NT). Resveratrol (18 mg/kg/day; HS-RSV) was given for 8 weeks after hypertension and cardiac hypertrophy were established (which occurred 3 weeks after salt addition). Resveratrol treatment improved survival (64% in HS-RSV versus 15% in HS-NT, p<0.001), and prevented the 25% reduction in body weight in HS-NT (P<0.001). Moreover, RSV counteracted the development of cardiac dysfunction (fractional shortening -34% in HS-NT) as evaluated by echocardiography, which occurred without regression of hypertension or hypertrophy. Moreover, aortic endothelial dysfunction present in HS-NT was prevented in resveratrol-treated rats. Resveratrol treatment tended to preserve mitochondrial mass and biogenesis and completely protected mitochondrial fatty acid oxidation and PPARα (peroxisome proliferator-activated receptor α) expression. We conclude that resveratrol treatment exerts beneficial protective effects on survival, endothelium-dependent smooth muscle relaxation and cardiac contractile and mitochondrial function, suggesting that resveratrol or metabolic activators could be a relevant therapy in hypertension-induced HF.
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Contributor : Renée Ventura-Clapier Connect in order to contact the contributor
Submitted on : Monday, December 12, 2011 - 5:26:09 PM
Last modification on : Wednesday, October 14, 2020 - 3:58:35 AM
Long-term archiving on: : Tuesday, March 13, 2012 - 2:35:49 AM


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Stéphanie Rimbaud, Matthieu Ruiz, Jérôme Piquereau, Philippe Mateo, Dominique Fortin, et al.. Resveratrol improves survival, hemodynamics and energetics in a rat model of hypertension leading to heart failure.. PLoS ONE, Public Library of Science, 2011, 6 (10), pp.e26391. ⟨10.1371/journal.pone.0026391⟩. ⟨inserm-00651075⟩



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