Report of depressive symptoms on waiting list and mortality after liver and kidney transplantation:a prospective cohort study. - Archive ouverte HAL Access content directly
Journal Articles BMC Psychiatry Year : 2011

Report of depressive symptoms on waiting list and mortality after liver and kidney transplantation:a prospective cohort study.

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Caroline Barry
  • Function : Author
  • PersonId : 910987
Isabelle Varescon
  • Function : Author
  • PersonId : 915361
Antoine Durrbach
  • Function : Author
  • PersonId : 915362
Didier Samuel
  • Function : Author
  • PersonId : 915363
Philippe Lang
  • Function : Author
  • PersonId : 915364
Denis Castaing
  • Function : Author
  • PersonId : 915365
Bernard Charpentier
  • Function : Author
  • PersonId : 915366

Abstract

ABSTRACT: BACKGROUND: Little research has explored pre-transplantation psychological factors as predictors of outcome after liver or kidney transplantation. Our objective is to determine whether report of depressive symptoms on waiting list predicts outcome of liver and kidney transplantation. METHODS: Patients on waiting list for liver or kidney transplantation were classified for report or non-report of depressive symptoms on waiting list. 339 were transplanted 6 months later on average, and followed prospectively. The main outcome measures were graft failure and mortality 18 months post-transplantation. RESULTS: Among the 339 patients, 51.6% reported depressive symptoms on waiting list, 16.5% had a graft failure and 7.4% died post-transplantation. Report of depressive symptoms on waiting list predicted a 3 to 4-fold decreased risk of graft failure and mortality 18-months post-transplantation, independently from age, gender, current cigarette smoking, anxiety symptoms, main primary diagnosis, UNOS score, number of comorbid diagnoses and history of transplantation. Data were consistent for liver and kidney transplantations. Other baseline predictive factors were: for graft failure, the main primary diagnosis and a shorter length since this diagnosis, and for mortality, older age, male gender and the main primary diagnosis. CONCLUSION: Further studies are needed to understand the underlying mechanisms of the association between report of depressive symptoms on waiting list and decreased risk of graft failure and mortality after transplantation.
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Dates and versions

inserm-00648985 , version 1 (06-12-2011)

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Emmanuelle Corruble, Caroline Barry, Isabelle Varescon, Antoine Durrbach, Didier Samuel, et al.. Report of depressive symptoms on waiting list and mortality after liver and kidney transplantation:a prospective cohort study.. BMC Psychiatry, 2011, 11 (1), pp.182. ⟨10.1186/1471-244X-11-182⟩. ⟨inserm-00648985⟩
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