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Compact and highly stable quantum dots through optimized aqueous phase transfer

Abstract : A large number of different approaches for the aqueous phase transfer of quantum dots have been proposed. Surface ligand exchange with small hydrophilic thiols, such as L-cysteine, yields the lowest hydrodynamic diameter. However, cysteine is prone to dimer formation, which limits colloidal stability. We demonstrate that precise pH control during aqueous phase transfer dramatically increases the colloidal stability of InP/ZnS quantum dots. Various bifunctional thiols have been applied. The formation of disulfides, strongly diminishing the fluorescence QY has been prevented through addition of appropriate reducing agents. Bright InP/ZnS quantum dots with a hydrodynamic diameter <10 nm and longterm stability have been obtained. Finally we present in vitro studies of the quantum dots functionalized with the cellpenetrating peptide maurocalcine
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Submitted on : Thursday, December 1, 2011 - 1:39:49 PM
Last modification on : Sunday, June 26, 2022 - 12:25:47 AM
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  • HAL Id : inserm-00647054, version 1



Sudarsan Tamang, Grégory Beaune, Cathy Poillot, Michel de Waard, Isabelle Texier-Nogues, et al.. Compact and highly stable quantum dots through optimized aqueous phase transfer. Colloidal quantum dots/Nanocrystals for biomedical applications VI, Jan 2011, San Francisco-CA, United States. pp.79091B-79091B-6. ⟨inserm-00647054⟩



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