Which SPM method should be used to extract hippocampal measures in early Alzheimer's disease? - Archive ouverte HAL Access content directly
Journal Articles J. Neuroimaging Year : 2011

Which SPM method should be used to extract hippocampal measures in early Alzheimer's disease?

(1) , (1) , (2) , (1) , (1) , (1, 3) , (1) , (1)
1
2
3

Abstract

BACKGROUND AND PURPOSE: To provide guidance regarding the most appropriate voxel-based morphometry (VBM)-derived method for assessing hippocampal atrophy in early Alzheimer's disease (AD). METHODS: T1-MRI volume data were collected in 23 patients with amnestic mild cognitive impairment (aMCI) and 18 controls. Three types of data (unmodulated and 2 types of modulated MRI) and 2 extraction methods (with reference to the hippocampal peak of atrophy identified from a preliminary whole-brain analysis, or using a template region of interest-ROI-approach) were compared to the gold-standard individual ROI (ROI-i) method through 2 statistical approaches (ANOVA and Pearson's R). RESULTS: First, whole-brain analyses performed on modulated data are as sensitive as the ROI-i approach in detecting aMCI patients' hippocampal atrophy. Second, values extracted from the ROI-template applied to modulated data provide measures of hippocampal volume comparable to those obtained using the ROI-i approach. CONCLUSIONS: This study provides guidance on how to extract accurate hippocampal measures from VBM-derived data in early AD, as a time-saving and easy alternative to the reference ROI-i method.
Fichier principal
Vignette du fichier
figures_JON_MEVEL.pdf (2.14 Mo) Télécharger le fichier
Vignette du fichier
Clinical_Investigative_Study_revised_HAL.pdf (271.64 Ko) Télécharger le fichier
Vignette du fichier
JON_548_sm_TableS1-S3.pdf (149.5 Ko) Télécharger le fichier
Origin : Files produced by the author(s)
Origin : Files produced by the author(s)
Origin : Files produced by the author(s)

Dates and versions

inserm-00646697 , version 1 (30-11-2011)

Identifiers

Cite

Katell Mevel, Béatrice Desgranges, Jean-Claude Baron, Brigitte Landeau, Vincent de La Sayette, et al.. Which SPM method should be used to extract hippocampal measures in early Alzheimer's disease?: SPM-derived hippocampal measurements. J. Neuroimaging, 2011, 21 (4), pp.310-6. ⟨10.1111/j.1552-6569.2010.00548.x⟩. ⟨inserm-00646697⟩
226 View
1287 Download

Altmetric

Share

Gmail Facebook Twitter LinkedIn More