Postcardiac arrest syndrome: from immediate resuscitation to long-term outcome.

Nicolas Mongardon 1 Florence Dumas 2 Sylvie Ricome 1 David Grimaldi 1 Tarik Hissem 1 Frédéric Pène 1 Alain Cariou 1, 2, *
* Auteur correspondant
1 Service de médecine d'urgence [CHU Cochin]
2 PARCC - U970 - Paris-Centre de Recherche Cardiovasculaire
Abstract : ABSTRACT: Prognosis of post-cardiac arrest patients remains very bleak, not only because of anoxic-ischemic neurological damage, but also because of the "post-cardiac arrest syndrome", a phenomenon often enough severe to cause death before any neurological evaluation. This syndrome includes all clinical and biological manifestations related to the phenomenon of global ischemia-reperfusion triggered by cardiac arrest and return of spontaneous circulation. The main component of the post-cardiac arrest syndrome is an early but severe cardio-circulatory dysfunction that may lead to multiple organ failure and death. Cardiovascular support relies on conventional medical and mechanical treatment of circulatory failure. Hemodynamic stabilization is a major objective to limit secondary brain insult. When the cause of cardiac arrest is related to myocardial infarction, percutaneous coronary revascularization is associated with improved prognosis; early angiographic exploration should then be discussed when there is no obvious extra-cardiac cause. Therapeutic hypothermia is now the cornerstone of post anoxic cerebral protection. Its widespread use is clearly recommended, with favourable risk-benefit ratio in selected population. Neuroprotection is also based on the prevention of secondary cerebral damages, pending the results of ongoing therapeutic evaluations regarding the potential efficiency of new therapeutic drugs.
Type de document :
Article dans une revue
Annals of Intensive Care, BioMed Central, 2011, 1 (1), pp.45. 〈10.1186/2110-5820-1-45〉
Liste complète des métadonnées

Littérature citée [49 références]  Voir  Masquer  Télécharger
http://www.hal.inserm.fr/inserm-00644392
Contributeur : Ed. Bmc <>
Soumis le : jeudi 24 novembre 2011 - 13:05:34
Dernière modification le : mercredi 10 janvier 2018 - 15:18:30
Document(s) archivé(s) le : vendredi 16 novembre 2012 - 11:55:50

Fichiers

2110-5820-1-45.pdf
Fichiers éditeurs autorisés sur une archive ouverte

Identifiants

Collections

UNIV-PARIS5 | USPC

Citation

Nicolas Mongardon, Florence Dumas, Sylvie Ricome, David Grimaldi, Tarik Hissem, et al.. Postcardiac arrest syndrome: from immediate resuscitation to long-term outcome.. Annals of Intensive Care, BioMed Central, 2011, 1 (1), pp.45. 〈10.1186/2110-5820-1-45〉. 〈inserm-00644392〉

Exporter

BibTeX TEI DC DCterms EndNote

Partager

Métriques

Consultations de la notice

212

Téléchargements de fichiers

133

Contact

support.ccsd.cnrs.fr
hal.support@ccsd.cnrs.fr
Logo CCSD