Carotid and femoral atherosclerotic plaques show different morphology.

Fanny Herisson; Marie-Françoise Heymann; Maud Chétiveaux; Céline Charrier; Séverine Battaglia; Paul Pilet; Thierry Rouillon; Michel Krempf; Patricia Lemarchand; Dominique Heymann; Yann Gouëffic

doi:10.1016/j.atherosclerosis.2011.02.004

Carotid and femoral atherosclerotic plaques show different morphology.: Patterns of Peripheral Arterial Disease

Fanny Herisson ^{1, 2} Marie-Françoise Heymann ^{1, 3} Maud Chétiveaux ⁴ Céline Charrier ¹ Séverine Battaglia ¹ Paul Pilet ⁵ Thierry Rouillon ⁵ Michel Krempf ^{4, 6} Patricia Lemarchand ^{4, 7} Dominique Heymann ¹ Yann Gouëffic ^{4, 6, 7, 8, *}

* Auteur correspondant

1 Physiopathologie de la Résorption Osseuse et Thérapie des Tumeurs Osseuses Primitives

2 Service de neurologie [Nantes]

3 Service d'Anatomo-pathologie

4 Institut du thorax

5 LIOAD - Laboratoire d'ingénierie osteo-articulaire et dentaire

6 Service d'endocrinologie

7 CIC biothérapies CBT 0503 [Nantes]

8 Service de chirurgie vasculaire

Abstract : OBJECTIVE: Results of endovascular repair vary according to the arterial bed. We hypothesized that these differences may be related to the plaque features. To explore this hypothesis, we designed a prospective study that compared carotid and femoral atheroma. METHODS AND RESULTS: Patients that underwent femoral or carotid endarterectomy were included in our study. Demographic data and blood sampling were obtained prior to surgery. Plaques were evaluated for AHA grading, calcification and lipid content. Eighty-eight plaques were harvested during this study (45 carotid specimens and 43 femoral specimens). No differences were noted between carotid and femoral groups regarding demographic and biological data. Histological data more frequently showed fibrous cap atheroma in carotid arteries (75%) and fibrocalcific plaques in femoral arteries (93%), p<0.001. Morphological analyses showed a high prevalence of osteoid metaplasia in femoral arteries (63%) compared to carotid arteries (20%, p<0.001). Biochemical analyses were consistent with histological data, showing higher calcium and lesser cholesterol concentrations in femoral than in carotid plaques (p<0.01). CONCLUSIONS: Femoral and carotid plaques showed different morphology in comparable groups of patients.

Keywords : Peripheral artery disease Atherosclerosis Vascular calcification Lipids

Type de document :

Article dans une revue

Atherosclerosis, Elsevier, 2011, 216 (2), pp.348-54. 〈10.1016/j.atherosclerosis.2011.02.004〉

Domaine :

Sciences du Vivant [q-bio] / Biologie cellulaire

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Carotid and femoral atherosclerotic plaques show different morphology.: Patterns of Peripheral Arterial Disease

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