A. Marmarou, A review of progress in understanding the pathophysiology and treatment of brain edema, Neurosurgical Focus, vol.22, issue.5, p.1, 2007.
DOI : 10.3171/foc.2007.22.5.2

K. Sandoval and K. Witt, Blood-brain barrier tight junction permeability and ischemic stroke, Neurobiology of Disease, vol.32, issue.2, pp.200-219, 2008.
DOI : 10.1016/j.nbd.2008.08.005

A. Unterberg, J. Stover, B. Kress, and K. Kiening, Edema and brain trauma, Neuroscience, vol.129, issue.4, pp.1021-1029, 2004.
DOI : 10.1016/j.neuroscience.2004.06.046

P. Agre, S. Nielsen, and O. Ottersen, Towards a molecular understanding of water homeostasis in the brain, Neuroscience, vol.129, issue.4, pp.849-850, 2004.
DOI : 10.1016/j.neuroscience.2004.10.001

N. Abbott, A. Patabendige, D. Dolman, S. Yusof, and D. Begley, Structure and function of the blood???brain barrier, Neurobiology of Disease, vol.37, issue.1, pp.13-25, 2010.
DOI : 10.1016/j.nbd.2009.07.030

A. Wunder, J. Klohs, and U. Dirnagl, Non-invasive visualization of CNS inflammation with nuclear and optical imaging, Neuroscience, vol.158, issue.3, pp.1161-1173, 2009.
DOI : 10.1016/j.neuroscience.2008.10.005

S. Nag, J. Manias, and D. Stewart, Pathology and new players in the pathogenesis of brain edema, Acta Neuropathologica, vol.57, issue.Pt 6, pp.197-217, 2009.
DOI : 10.1007/s00401-009-0541-0

M. Tait, S. Saadoun, B. Bell, and M. Papadopoulos, Water movements in the brain: role of aquaporins, Trends in Neurosciences, vol.31, issue.1, pp.37-43, 2008.
DOI : 10.1016/j.tins.2007.11.003

O. Bloch, M. Papadopoulos, G. Manley, and A. Verkman, Aquaporin-4 gene deletion in mice increases focal edema associated with staphylococcal brain abscess, Journal of Neurochemistry, vol.43, issue.1, pp.254-262, 2005.
DOI : 10.1111/j.1471-4159.2005.03362.x

G. Manley, D. Binder, M. Papadopoulos, and A. Verkman, New insights into water transport and edema in the central nervous system from phenotype analysis of aquaporin-4 null mice, Neuroscience, vol.129, issue.4, pp.983-991, 2004.
DOI : 10.1016/j.neuroscience.2004.06.088

M. Papadopoulos, G. Manley, S. Krishna, and A. Verkman, Aquaporin-4 facilitates reabsorption of excess fluid in vasogenic brain edema, The FASEB Journal, vol.18, pp.1291-1293, 2004.
DOI : 10.1096/fj.04-1723fje

T. Tourdias, I. Dragonu, Y. Fushimi, M. Deloire, C. Boiziau et al., Aquaporin 4 correlates with apparent diffusion coefficient and hydrocephalus severity in the rat brain: A combined MRI???histological study, NeuroImage, vol.47, issue.2, pp.659-666, 2009.
DOI : 10.1016/j.neuroimage.2009.04.070

M. Deloire-grassin, B. Brochet, B. Quesson, C. Delalande, V. Dousset et al., In vivo evaluation of remyelination in rat brain by magnetization transfer imaging, Journal of the Neurological Sciences, vol.178, issue.1, pp.10-16, 2000.
DOI : 10.1016/S0022-510X(00)00331-2

S. Bustin, V. Benes, J. Garson, J. Hellemans, J. Huggett et al., The MIQE Guidelines: Minimum Information for Publication of Quantitative Real-Time PCR Experiments, Clinical Chemistry, vol.55, issue.4, pp.611-622, 2009.
DOI : 10.1373/clinchem.2008.112797

K. Livak and T. Schmittgen, Analysis of relative gene expression data using real-time quantitative PCR and the 2(-Delta Delta C(T)) Method, pp.402-408, 2001.

M. Amiry-moghaddam, T. Otsuka, P. Hurn, R. Traystman, F. Haug et al., An ??-syntrophin-dependent pool of AQP4 in astroglial end-feet confers bidirectional water flow between blood and brain, Proceedings of the National Academy of Sciences, vol.100, issue.4, pp.2106-2111, 2003.
DOI : 10.1073/pnas.0437946100

G. Manley, M. Fujimura, T. Ma, N. Noshita, F. Filiz et al., Aquaporin-4 deletion in mice reduces brain edema after acute water intoxication and ischemic stroke, Nature Medicine, vol.6, issue.2, pp.159-163, 2000.
DOI : 10.1038/72256

M. Papadopoulos and A. Verkman, Aquaporin-4 Gene Disruption in Mice Reduces Brain Swelling and Mortality in Pneumococcal Meningitis, Journal of Biological Chemistry, vol.280, issue.14, pp.13906-13912, 2005.
DOI : 10.1074/jbc.M413627200

Z. Vajda, M. Pedersen, E. Fuchtbauer, K. Wertz, H. Stodkilde-jorgensen et al., Delayed onset of brain edema and mislocalization of aquaporin-4 in dystrophin-null transgenic mice, Proceedings of the National Academy of Sciences, vol.99, issue.20, pp.13131-13136, 2002.
DOI : 10.1073/pnas.192457099

O. Bloch, K. Auguste, G. Manley, and A. Verkman, Accelerated Progression of Kaolin-Induced Hydrocephalus in Aquaporin-4-Deficient Mice, Journal of Cerebral Blood Flow & Metabolism, vol.53, issue.12, pp.1527-1537, 2006.
DOI : 10.1038/sj.jcbfm.9600306

S. Nielsen, E. Nagelhus, M. Amiry-moghaddam, C. Bourque, P. Agre et al., Specialized membrane domains for water transport in glial cells: high-resolution immunogold cytochemistry of aquaporin-4 in rat brain, J Neurosci, vol.17, pp.171-180, 1997.

S. Saadoun and M. Papadopoulos, Aquaporin-4 in brain and spinal cord oedema, Neuroscience, vol.168, issue.4, pp.1036-1046, 2010.
DOI : 10.1016/j.neuroscience.2009.08.019

S. Lakhan, A. Kirchgessner, and M. Hofer, Inflammatory mechanisms in ischemic stroke: therapeutic approaches, Journal of Translational Medicine, vol.7, issue.1, p.97, 2009.
DOI : 10.1186/1479-5876-7-97

C. Stock, T. Schilling, A. Schwab, and C. Eder, Lysophosphatidylcholine Stimulates IL-1?? Release from Microglia via a P2X7 Receptor-Independent Mechanism, The Journal of Immunology, vol.177, issue.12, pp.8560-8568, 2006.
DOI : 10.4049/jimmunol.177.12.8560

L. Bihan and D. , Looking into the functional architecture of the brain with diffusion MRI, Nature Reviews Neuroscience, vol.4, issue.6, pp.469-480, 2003.
DOI : 10.1038/nrn1119

URL : https://hal.archives-ouvertes.fr/hal-00349696

H. Agrawal, J. Davis, and W. Himwich, DEVELOPMENTAL CHANGES IN MOUSE BRAIN: WEIGHT, WATER CONTENT AND FREE AMINO ACIDS, Journal of Neurochemistry, vol.3, issue.170, pp.917-923, 1968.
DOI : 10.1111/j.1471-4159.1968.tb11633.x

D. Frydenlund, A. Bhardwaj, T. Otsuka, M. Mylonakou, T. Yasumura et al., Temporary loss of perivascular aquaporin-4 in neocortex after transient middle cerebral artery occlusion in mice, Proceedings of the National Academy of Sciences, vol.103, issue.36, pp.13532-13536, 2006.
DOI : 10.1073/pnas.0605796103

R. Mde, C. Hirt, L. Bogousslavsky, J. Regli, L. Badaut et al., Time course of aquaporin expression after transient focal cerebral ischemia in mice, J Neurosci Res, vol.83, pp.1231-1240, 2006.

C. Ke, W. Poon, H. Ng, J. Pang, and Y. Chan, Heterogeneous responses of aquaporin-4 in oedema formation in a replicated severe traumatic brain injury model in rats, Neuroscience Letters, vol.301, issue.1, pp.21-24, 2001.
DOI : 10.1016/S0304-3940(01)01589-0

K. Kiening, F. Van-landeghem, S. Schreiber, U. Thomale, A. Von-deimling et al., Decreased hemispheric Aquaporin-4 is linked to evolving brain edema following controlled cortical impact injury in rats, Neuroscience Letters, vol.324, issue.2, pp.105-108, 2002.
DOI : 10.1016/S0304-3940(02)00180-5

K. Auguste, J. S. Uchida, K. Yan, D. Manley, G. Papadopoulos et al., Greatly impaired migration of implanted aquaporin-4-deficient astroglial cells in mouse brain toward a site of injury, The FASEB Journal, vol.21, issue.1, pp.108-116, 2007.
DOI : 10.1096/fj.06-6848com

S. Saadoun, M. Papadopoulos, H. Watanabe, D. Yan, G. Manley et al., Involvement of aquaporin-4 in astroglial cell migration and glial scar formation, Journal of Cell Science, vol.118, issue.24, pp.5691-5698, 2005.
DOI : 10.1242/jcs.02680

M. Tomas-camardiel, J. Venero, A. Herrera, D. Pablos, R. Pintor-toro et al., Blood-brain barrier disruption highly induces aquaporin-4 mRNA and protein in perivascular and parenchymal astrocytes: Protective effect by estradiol treatment in ovariectomized animals, Journal of Neuroscience Research, vol.22, issue.2, pp.235-246, 2005.
DOI : 10.1002/jnr.20443

M. Vizuete, J. Venero, C. Vargas, A. Ilundain, M. Echevarria et al., Differential Upregulation of Aquaporin-4 mRNA Expression in Reactive Astrocytes after Brain Injury: Potential Role in Brain Edema, Neurobiology of Disease, vol.6, issue.4, pp.245-258, 1999.
DOI : 10.1006/nbdi.1999.0246