Can We Remember Future Actions yet Forget the Last Two Minutes? Study in Transient Global Amnesia. - Archive ouverte HAL Access content directly
Journal Articles Journal of Cognitive Neuroscience Year : 2011

Can We Remember Future Actions yet Forget the Last Two Minutes? Study in Transient Global Amnesia.

(1) , (1) , (1) , (2, 3) , (2, 3) , (4) , (4) , (4)
1
2
3
4

Abstract

Transient global amnesia (TGA) is a clinical syndrome characterized by the abrupt onset of a massive episodic memory deficit that spares other cognitive functions. If the anterograde dimension is known to be impaired in TGA, researchers have yet to investigate prospective memory (PM)-which involves remembering to perform an intended action at some point in the future-in this syndrome. Furthermore, as executive functions are thought to be spared in this syndrome, TGA provides an opportunity to examine the impact of a massive "pure" memory impairment on PM. We assessed 38 patients with a newly designed protocol that distinguished between the prospective (remembering to do something at the appropriate time) and retrospective (remembering what has to be done) components of PM. Moreover, we investigated episodic memory with an anterograde memory task and assessed executive functions, anxiety and mood, as well as their links with PM. We demonstrated that PM is impaired during TGA, with a greater deficit for the retrospective component than for the prospective component. Furthermore, we highlighted a strong link between these two components. Anterograde episodic memory impairments were correlated with retrospective component deficits in TGA patients, although we were able to confirm that executive functions are globally spared. We discuss this pattern of results within the theoretical framework of PM, putting forward new arguments in favor of the idea that PM deficits can occur mainly because of a massive anterograde memory deficit. The clinical consequences of PM impairment in TGA are examined.
Fichier principal
Vignette du fichier
jocn_a_00076.pdf (277.54 Ko) Télécharger le fichier
Origin : Publisher files allowed on an open archive
Loading...

Dates and versions

inserm-00642099 , version 1 (17-11-2011)

Identifiers

Cite

Mathieu Hainselin, Peggy Quinette, Béatrice Desgranges, Olivier Martinaud, Didier Hannequin, et al.. Can We Remember Future Actions yet Forget the Last Two Minutes? Study in Transient Global Amnesia.: Prospective memory in TGA. Journal of Cognitive Neuroscience, 2011, 23 (12), pp.4138-49. ⟨10.1162/jocn_a_00076⟩. ⟨inserm-00642099⟩
291 View
1112 Download

Altmetric

Share

Gmail Facebook Twitter LinkedIn More