La neutrophil gelatinase-associated lipocalin, ou LCN 2, facteur d'agressivité dans le carcinome rénal à cellules claires (CRCC). [The neutrophil gelatinase-associated lipocalin, or LCN 2, marker of aggressiveness in clear cell renal cell carcinoma].

Christophe Perrin 1, 2, 3 Jean-Jacques Patard 1, 4 Florence Jouan 1 Nicolas Collet 5 Sandrine Théoleyre 1, 5 Julien Edeline 1, 2, 3 Salim Zerrouki 5 Brigitte Laguerre 2, 3 Marc-Antoine Belaud-Rotureau 1, 6 Nathalie Rioux-Leclercq 1, * Cécile Vigneau 1, 7
* Auteur correspondant
1 IGDR - Institut de Génétique et Développement de Rennes
2 Service d'anatomie et cytologie pathologiques [Rennes]
3 CRLCC - CRLCC Eugène Marquis
4 Service d'urologie
5 Service de Néphrologie
6 Service de Cytogénétique et de Biologie Cellulaire
7 Service de néphrologie
Abstract : OBJECTIVE: To determine the prognostic significance of the neutrophil gelatinase-associated lipocalin (NGAL) and the matrix metalloproteinase 9 (MMP-9) in clear cell renal cell carcinoma (CCRCC). PATIENTS AND METHODS: NGAL and MMP-9 expression were quantified by immunohistochemistry in clear renal cell carcinoma tissues and in sera by Enzyme Linked Immunosorbent Assay (Elisa). Results were associated with clinicopathologic data. RESULTS: Seventy-four patients operated for CCRCC in Rennes between 2003 and 2009 were included. High concentrations of NGAL-MMP-9 complex in serum were associated with short progression free survival (PFS) (33.3 months versus 47.3 months, P=0.016) and poor overall survival (42.5 months versus 51.9 months, P<0.047). High NGAL concentrations in serum were also associated with shorter PFS (13.6 months versus 41.6 months, P=0.04). However, no NGAL expression was observed in renal tumor cells. Interestingly, NGAL was expressed by neutrophils infiltrating CCRCC and we showed that the density of NGAL expressing neutrophils was associated with pejorative PFS and survival (36.9months versus 56.1 months, P<0.006). CONCLUSION: In this study, we showed the pejorative significance of NGAL-MMP-9 complex and NGAL rates in serum of CCRCC. We also confirmed that density of NGAL expressing neutrophils in CCRCC was associated with poor outcome.
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Article dans une revue
Progrès en Urologie, Elsevier Masson, 2011, 21 (12), pp.851-8. 〈10.1016/j.purol.2011.06.005〉
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http://www.hal.inserm.fr/inserm-00638985
Contributeur : Hervé De Villemeur <>
Soumis le : lundi 7 novembre 2011 - 17:51:48
Dernière modification le : mercredi 16 mai 2018 - 11:23:34

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IGDR | BIOSIT | UR1-UFR-SVE | MARQUIS | FNCLCC | UNIV-RENNES

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Christophe Perrin, Jean-Jacques Patard, Florence Jouan, Nicolas Collet, Sandrine Théoleyre, et al.. La neutrophil gelatinase-associated lipocalin, ou LCN 2, facteur d'agressivité dans le carcinome rénal à cellules claires (CRCC). [The neutrophil gelatinase-associated lipocalin, or LCN 2, marker of aggressiveness in clear cell renal cell carcinoma].. Progrès en Urologie, Elsevier Masson, 2011, 21 (12), pp.851-8. 〈10.1016/j.purol.2011.06.005〉. 〈inserm-00638985〉

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