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A mechanism-based model for the population pharmacokinetics of free and bound aflibercept in healthy subjects.

Abstract : AIM: Aflibercept (VEGF-Trap), a novel anti-angiogenic agent that binds to VEGF, has been investigated for the treatment of cancer. The aim of this study was to develop a mechanism-based pharmacokinetic (PK) model for aflibercept to characterize its binding to VEGF and its PK properties in healthy subjects. METHODS: Data from two phase I clinical studies with aflibercept administered as a single intravenous infusion were included in the analysis. Free and bound aflibercept concentration-time data were analysed using a nonlinear mixed-effects modelling approach with MONOLIX 3.1. RESULTS: The best structural model involved two compartments for free aflibercept and one for bound aflibercept, with a Michaelis-Menten type binding of free aflibercept to VEGF from the peripheral compartment. The typical estimated clearances for free and bound aflibercept were 0.88 l day(-1) and 0.14 l day(-1), respectively. The central volume of distribution of free aflibercept was 4.94 l. The maximum binding capacity was 0.99 mg day(-1) and the concentration of aflibercept corresponding to half of maximum binding capacity was 2.91 µg ml(-1). Interindividual variability of model parameters was moderate, ranging from 13.6% (V(max) ) to 49.8% (Q). CONCLUSION: The present PK model for aflibercept adequately characterizes the underlying mechanism of disposition of aflibercept and its nonlinear binding to VEGF.
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Submitted on : Thursday, October 6, 2011 - 4:04:43 PM
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Hoai-Thu Thai, Christine Veyrat-Follet, Nicole Vivier, Catherine Dubruc, Gérard Sanderink, et al.. A mechanism-based model for the population pharmacokinetics of free and bound aflibercept in healthy subjects.. British Journal of Clinical Pharmacology, Wiley, 2011, 72 (3), pp.402-14. ⟨10.1111/j.1365-2125.2011.04015.x⟩. ⟨inserm-00629806⟩



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