Increased Atherosclerosis in Mice Deficient in Perilipin1. - Archive ouverte HAL Access content directly
Journal Articles Lipids in Health and Disease Year : 2011

Increased Atherosclerosis in Mice Deficient in Perilipin1.

(1) , (1) , (1) , (1, 2) , (1) , (1, 2)
1
2

Abstract

ABSTRACT: BACKGROUND: Perilipin1, a lipid droplet associated protein has an important role in the regulation of lipolysis and lipid storage in adipocytes. Perilipin1 is also expressed in foam cells of atheroma plaques and could therefore play a role in the accumulation of lipids in arterial wall and in the development of atherosclerosis. The aim of the study was to investigate this possible role of perilipin1 in atherogenesis. METHODS: Mice deficient in perilipin1 (Plin1-/-) were crossed with Ldlr-/- mice. Ldlr-/- and Plin1-/- Ldlr-/- mice received an atherogenic diet during 10 or 20 weeks. Blood pressure and plasma lipids concentrations were measured. Aortas were collected at the end of the atherogenic diet periods for quantification of atheroma lesions (en face method), histological and immunohistological studies RESULTS: Ldlr-/- and Plin1-/- Ldlr-/- mice had comparable blood pressure and plasma lipids levels. Plin1-/- Ldlr-/- mice had a lower body weight and decreased adiposity. The atherosclerotic lesion area in Plin1-/-Ldlr-/- mice was moderately increased after 10 weeks of atherogenic diet (ns) and significantly higher after 20 weeks (p<0.01). Histology of atherome plaques was comparable with no sign of increased inflammation in Plin1-/- Ldlr-/- mice. CONCLUSION: Perilipin1 ablation in mice results in increased atherosclerosis independently of modifications of risk factors such as raised blood pressure or plasma lipids levels. These data strongly support an atheroprotective role for perilipin1.
Fichier principal
Vignette du fichier
1476-511X-10-169.pdf (701.26 Ko) Télécharger le fichier
Vignette du fichier
1476-511X-10-169.xml (43.08 Ko) Télécharger le fichier
Origin : Publisher files allowed on an open archive
Format : Other

Dates and versions

inserm-00629632 , version 1 (06-10-2011)

Identifiers

Cite

Dominique Langlois, Fabien Forcheron, Jacques-Yuan Li, Peggy del Carmine, Samia Neggazi, et al.. Increased Atherosclerosis in Mice Deficient in Perilipin1.. Lipids in Health and Disease, 2011, 10 (1), pp.169. ⟨10.1186/1476-511X-10-169⟩. ⟨inserm-00629632⟩
134 View
240 Download

Altmetric

Share

Gmail Facebook Twitter LinkedIn More